Visual Remapping to Aid Reading With Field Loss
ConditionAge-related Macular Degeneration
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age16+
SponsorUniversity of Minnesota
About this trial
Reading performance in patients with Central Vision Loss and age matched controls with artificial scotomas will be measured with and without different kinds of remapping of missing text to different parts of the visual field.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
16 years or older
Central vision loss of at least 5 deg diameter, including the fovea, from bilateral central scotomas
Stable fixation (+/- 1 deg) using their PRL.
No cognitive impairment as indicated by a Mini-Mental State Examination (MMSE).
Disqualifiers
Central vision loss of less than 5 deg diameter; scotomas that do not cover the fovea; unilateral scotomas
Poor fixation (worse than+/- 1 deg) using their PRL.
Cognitive impairment as indicated by a Mini-Mental State Examination (MMSE).
Satisfactory calibration not achievable using eye tracker
Trial design
Design model
Parallel
Treatments tested in this trial
Traditional Remapping
BehavioralShifting text outside of scotoma
Personalized Remapping
BehavioralShifting text based on individual letter-based perimetry
Treatment groups
108 Participants
are divided into 2 treatment groupsGroup A: Patients with scotomaExperimental treatment 2 interventions
Group B: Normally sighted with artificial scotomaActive comparator 2 interventions
Trial outcomes
Primary outcomes
1
Reading Speed for Individual Words
How quickly participants can correctly read displayed text
Time frame
Measured during third visit- each visit is one day only and this measure refers to data gathered during a < 1 hr long reading session during that day2
Reading Speed for Sentences
How quickly participants can correctly read displayed text
Time frame
Measured during fourth visit- each visit is one day only and this measure refers to data gathered during a < 1 hr long reading session during that day3
Reading Speed for Natural Text Samples
How quickly participants can correctly read displayed text
Time frame
Measured during fifth visit; each visit is one day only and this measure refers to data gathered during a < 1 hr long reading session during that day4
Reading error rate for Individual Words
How many mistakes participants make
Time frame
Measured during third visit; each visit is one day only and this measure refers to data gathered during a < 1 hr long reading session during that daySecondary outcomes
1
Eye fixation quality for words
Variance of x and y eye position coordinates computed during fixation periods while reading
Time frame
Measured during third visit; each visit is one day only and this measure refers to data gathered during a < 1 hr long reading session during that day2
Eye fixation quality for sentences
Variance of x and y eye position coordinates computed during fixation periods while reading
Time frame
Measured during fourth visit; each visit is one day only and this measure refers to data gathered during a < 1 hr long reading session during that day3
Eye movement quality for sentences
Number off leftward (regressive) eye movements during sentence reading
Time frame
Measured during fourth visit4
Eye fixation quality for natural text samples
Variance of x and y eye position coordinates computed during fixation periods while reading
Time frame
Measured during fifth visit; each visit is one day only and this measure refers to data gathered during a < 1 hr long reading session during that daySponsors and contacts
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Source ClinicalTrials.gov