This cross-sectional observational study aims to assess serum concentrations of vitamin B12, folic acid, and vitamin D in women of reproductive age in Herzegovina. The study is led by Professor Vajdana Tomić, MD, PhD, who serves as the Principal Investigator, at the Faculty of Health Studies, University of Mostar, Bosnia and Herzegovina. The goal is to determine whether current international supplementation guidelines reflect the actual micronutrient status of this population. A total of 360 women aged 18-49 will be enrolled between December 2024 and December 2025 after providing informed consent. The findings will inform population-specific recommendations for micronutrient supplementation during the preconception period and pregnancy.
The study will be conducted at the Faculty of Health Studies, University of Mostar, Bosnia and Herzegovina.
Women of reproductive age (18-49 years)
Informed consent obtained
diabetes (Type I or II)
epilepsy
oncological diseases, inflammatory bowel disease
supplementation with vitamin B12, folic acid, or vitamin D within the last 3 months
This study includes approximately 360 healthy women aged 18 to 49 years from the Herzegovina region who participate after providing written informed consent. All participants are being screened according to defined inclusion and exclusion criteria. The study focuses on assessing serum concentrations of vitamin B12, folic acid, and vitamin D to support the development of population-specific supplementation guidelines for the preconception period and pregnancy.
Other
Prospective
No Interventions
Other interventionThis is an observational study. No intervention will be administered. Participants will provide blood samples for micronutrient analysis.
Serum concentration of folic acid
Measured in serum samples using Alinity i immunoassay system.
Serum concentration of vitamin B12
Measured in serum samples using Alinity i immunoassay system.
Serum concentration of vitamin D
Measured in serum samples using Alinity i immunoassay system.
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University of Mostar
Lead sponsor
Faculty of Health Studies - University of Mostar
Collaborator
Primary Health Care Center Mostar
Collaborator
University Clinical Hospital Mostar
Collaborator