What is the Effect of Acute Kidney Injury on Weaning From Mechanical Ventilation in Critically Ill Adult Patients?
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorAssiut University
About this trial
The aim of this study is to evaluate the impact of acute kidney injury (AKI) on the success rate, duration, and complications of weaning from mechanical ventilation in critically ill adult patients admitted to the intensive care unit (ICU), and to identify whether AKI is an independent predictor of difficult, failed or complicated or weaning.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
• Age ≥ 18 years of either sex.
Admission to the ICU and receiving invasive mechanical ventilation via endotracheal tube.
Expected duration of mechanical ventilation ≥ 24 hours.
Hemodynamically stable or stabilized at the time of first spontaneous breathing trial (SBT) according to unit protocol (e.g., mean arterial pressure ≥ 65 mmHg with or without low dose vasopressors).
Disqualifiers
Pre existing end stage renal disease on chronic dialysis (hemodialysis or peritoneal dialysis).
Known advanced chronic kidney disease (e.g., baseline estimated GFR < 30 mL/min/1.73 m²) if baseline creatinine is available.
Previous tracheostomy before current ICU admission.
Neuromuscular diseases or spinal cord injury causing chronic ventilatory dependence.
Trial population
Critically ill patients 18 years or above with acute kidney injury.
Trial design
Design model
Other
Time perspective
Cross-sectional
Treatments tested in this trial
Acute Kidney Injury (AKI) Exposure
Other interventionParticipants will be categorized according to the presence or absence of Acute Kidney Injury during their ICU stay. All patients will undergo standard management of Mechanical Ventilation and routine weaning protocols as per ICU practice. The study will evaluate the association between AKI and outcomes of Weaning from Mechanical Ventilation, including success rate, duration, and complications.
Treatment groups
No treatment groups listed
Trial outcomes
Primary outcomes
1
Weaning success rate
Weaning from mechanical ventilation success: defined as extubation with no need for reintubation or invasive mechanical ventilation within 48-72 hours (use the definition adopted by your ICU).
Time frame
1 yearLocations
Sponsors and contacts
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Source ClinicalTrials.gov
This trial is not recruiting at the moment. You can still explore other options: