Which Rapid Sequence Induction Technique Should be Used in Urgent Surgery in Children?
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age1-14
SponsorTunis University
About this trial
The goal of our study is to compare classical Rapid Sequence Induction (RSI) and modified Rapid Sequence Induction (mRSI) in pediatric patients with a full stomach undergoing urgent surgical procedures. Due to reduced oxygen reserve in children, modified RSI incorporating gentle positive pressure ventilation has been proposed to reduce hypoxemia while maintaining protection against aspiration.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
children under 14 years of age with a full stomach, scheduled for urgent surgery under general anesthesia
Disqualifiers
hemodynamic instability
Trial design
Design model
Parallel
Treatments tested in this trial
Classical Rapid Sequence Induction
Other interventionPatients received propofol (3-5 mg/kg) until loss of consciousness, followed by succinylcholine (1-2 mg/kg, adjusted for age). Tracheal intubation was performed 30 seconds after the completion of induction, without any positive pressure ventilation
Modified Rapid Sequence Induction
Other interventionPatients received fentanyl (4 µg/kg), followed by propofol and succinylcholine at the same doses as in the RSI group. Following induction, patients received gentle positive pressure ventilation using the anesthesia machine in inspiratory support mode (inspiratory pressure: 10 cmH₂O; PEEP: 5 cmH₂O) for 30 seconds before tracheal intubation
Treatment groups
100 Participants
are divided into 2 treatment groupsGroup A: Classical Rapid Sequence Induction groupActive comparator 1 intervention
Group B: Modified Rapid Sequence Induction (mRSI) groupExperimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
Peri-Intubation Respiratory and Hemodynamic Complications in Children: Classical vs. Modified Rapid Sequence Induction
Time frame
From induction of anesthesia to 5 minutes after tracheal intubationSponsors and contacts
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Source ClinicalTrials.gov
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