Whole Body MRI for Non-invasive Lesion Detection and Therapy Follow-up: Study With Patients With Radiographic axSpA and Non-radiographic axSpA

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorThe First Affiliated Hospital with Nanjing Medical University

About this trial

This study aims to further improve and expand the WB-MRI imaging evaluation cohort of axSpA patients to complete dynamic follow-up and condition assessment. Based on the WB-MRI features, the association of WB-MRI signs with disease activity, inflammation, and structural damage will be analyzed. At the same time, in-depth data mining was conducted and machine learning was used to construct a new axSpA disease activity assessment model based on WB-MRI data, and the accuracy and reliability of the model were clearly evaluated in the discovery cohort and validation cohort.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

None

Disqualifiers

None

Trial population

Exclusion Criteria: Unable to provide written consent Unable to undergo MRI examination Pregnancy Unable to read and/or write Chinese

Trial design

Design model

Case-only

Time perspective

Prospective

Treatments tested in this trial

  • Whole body MRI

    Procedure/Surgery

    These studies will be performed on a 3Tesla (T) MR system (Achieva, Philips Medical Systems) for all patients.

Treatment groups

No treatment groups listed

Trial outcomes

Primary outcomes

1

WB-MRI imaging characteristics of patients with axSpA.

Compare the correlation between WB-MRI changes and disease activity, disease progression and structural damage at baseline and after 2 years of follow-up.

Time frame
Two years

Secondary outcomes

1

The correlation between WB-MRI changes and disease activities

To elucidate the correlation between WB-MRI changes and inflammation, structural damage and disease activity in patients with axSpA.

Time frame
Five yeas

Other outcomes

Sponsors and contacts

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