The investigators aim is to investigate the brain's dynamic complexity across three phases of an ovarian stimulation cycle (basal, pre-OPU, mid-luteal), to observe the impact of externally administered hormones, and compare it with the corresponding phases of a natural menstrual cycle (early follicular, pre-ovulatory, mid-luteal) in the same woman. Brain activity patterns will be examined using resting-state fMRI in a sample of young, healthy, naturally cycling women.
Age group: 25 - 35 years old
BMI: 20 - 30
Anti-Mullerian Hormone (AMH): 1.3 - 5.9 ng/ml
Regular Menstrual Cycle: 26-35 days
History of ovarian surgery
Pathology of the ovaries
Mental health disorders
Use of medication influencing brain function
Young (age range 25-35), healthy, naturally cycling women with a normal BMI, who want to undergo ovarian stimulation for oocyte vitrification.
Case-only
Prospective
Functional Magnetic resonance imaging will be done on day 2 or 3 of the menstrual cycle, trigger-shot and egg retrieval.
Diagnostic testFunctional Magnetic resonance imaging will be done on day 2 or 3 of the menstrual cycle, trigger-shot and egg retrieval.
Brain activity using functional magnetic resonance imaging (fMRI).
Comparison of brain activity between the natural menstrual cycle and a stimulated cycles using functional magnetic resonance imaging (fMRI) at three cycle points.
Hormonal levels (Estradiol, LH, FSH, Progesterone) fluctuation.
Analyze relation of hormonal fluctuations (Estradiol, LH, FSH, Progesterone) at three cycle points with brain dynamics and neural connectivity.
Whole genome sequencing of patient.
Sequence patient's genome using saliva sampling to observes the genetic basis of fertility traits, to identify genetic variants associated with various neural and fertility phenotypes.
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ART Fertility Clinics LLC
Lead sponsor
Khalifa University for Science and Technology
Collaborator
New York University Abu Dhabi
Collaborator
