Wise Choices in the Intensive Care Unit

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorKarolinska Institutet

About this trial

Aim: to evaluate if the Choosing Wisely campaign can be introduced without harming critically ill patients.

Background: Each year, around 45,000 patients are admitted to Sweden's 81 ICUs (intensive care units), costing 6-7 billion SEK (6% of total healthcare expenditure). The high costs of health care are partly attributable to overuse of diagnostic tests. Up to 30% of these tests lead to treatments that provide no benefit for patients, some of them may even be harmful(1-3). To improve quality of care while combating this problem of cost, the American Board of Internal Medicine Foundation developed the Choosing Wisely Campaign, tasking professional societies to develop lists of top five medical services patients and physicians should question. Patients in the ICU, can especially benefit from this paradigm shift. They are subjected to multiple testing on a daily - sometimes hourly - basis, therefore this field of medicine responded to the campaign quickly. Two sets of top-five-lists of tests and interventions that can be questioned have been published(4 5).

In multiple countries, including Sweden, the Choosing Wisely campaign is gathering traction among critical care physicians and is on the verge of being introduced. It is both common-sensical and will save money, so health care leaders are positive. However, the investigators have an opportunity, and a duty, to assess the evidence; can the Choosing Wisely campaign be introduced without harming ICU patients?

The present study thus aims to evaluate the introduction of the Choosing Wisely campaign in the context of the ICU. Is this change of care strategy associated with changes in 30-day-mortality? Secondary outcomes include ICU length of stay, use of non-invasive- or invasive mechanical ventilation and continuous renal replacement therapy. This is a registry-based cluster randomized controlled study (R-RCT), targeting Swedish ICU's across multiple regions. Primary and secondary outcomes will be retrieved from the Swedish Intensive care Register (SIR), making ICU participation easier and less costly.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Patients 18 years or older, treated in Swedish ICU's

Disqualifiers

Patients under the age of 18 years

Trial design

Design model

Sequential

Treatments tested in this trial

  • Choosing wisely protocol

    Procedure/Surgery

    Se arm description

Treatment groups

10,000 Participants
are divided into 2 treatment groups
Group A: Choosing wisely interventionActive comparator 1 intervention
Group B: Choosing wisely controlNo intervention 0 interventions

Trial outcomes

Primary outcomes

1

30-day mortality

Death within 30 days of ICU admission

Time frame
30 days after index ICU admission

Secondary outcomes

1

ICU length of stay

Days in the ICU after index ICU admission

Time frame
Up to one year after index ICU admission
2

Time in invasive/ non-invasive mechanical ventilation

Days in the ICU in invasive or non-invasive mechanical ventilation

Time frame
Up to one year after index ICU admission
3

Time on continuous renal replacement therapy

Days in the ICU on continuous renal replacement therapy

Time frame
Up to one year after index ICU admission
4

ICU readmission

Unplanned ICU readmission within 72h of ICU discharge

Time frame
72 hours post ICU discharge

Other outcomes

1

ICU readmission

Readmissions after ICU discharge

Time frame
Within 72 hours of ICU discharge

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Karolinska Institutet

Lead sponsor

Uppsala-Örebro Regional Research Council

Collaborator

Vastra Gotaland Region

Collaborator

Region Jönköping County

Collaborator

Region Skane

Collaborator

Region Stockholm

Collaborator

Sormland County Council, Sweden

Collaborator