Within-Individual Variability of Resting Metabolic Rate Over 12 Weeks
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-65
SponsorTel Aviv University
About this trial
This prospective observational study aims to characterize within-individual variability in resting metabolic rate (RMR) over a 12-week period using high-frequency repeated measurements under standardized conditions. Participants will undergo RMR assessments three times per week using whole-room indirect calorimetry.
The study will quantify the magnitude of physiological variability in RMR, distinguish true biological variation from measurement error, and estimate the minimal detectable change required to identify meaningful metabolic adaptations.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Adults aged 18-65 years
Clinically healthy individuals
Stable body weight (±2 kg) over the past 3 months
Ability and willingness to attend morning measurements three times per week for 12 weeks
Disqualifiers
Known uncontrolled endocrine or metabolic disease
Use of medications known to significantly affect resting metabolic rate (e.g., systemic corticosteroids, unstable thyroid hormone therapy)
Acute illness within 14 days prior to enrollment
Pregnancy or lactation
Trial population
Healthy adult men and women from the community, aged 18-65 years, who are clinically healthy and able to participate in repeated metabolic measurements under standardized laboratory conditions.
Trial design
Design model
Other
Time perspective
Prospective
Treatments tested in this trial
Repeated Measurement of Resting Metabolic Rate
Other interventionRepeated assessment of resting metabolic rate under standardized conditions; no intervention is administered.
Treatment groups
30 Participants
are divided into 1 treatment groupGroup A: Healthy Adults1 intervention
Trial outcomes
Primary outcomes
1
Within-Individual Variability in Resting Metabolic Rate (RMR)
Within-individual variability in resting metabolic rate (RMR) assessed using repeated measurements under standardized conditions. Variability will be quantified using mean, standard deviation (SD), and coefficient of variation (CV%) across repeated measurements.
Time frame
12 weeksSecondary outcomes
1
Minimal Detectable Change (MDC) in RMR
The minimal detectable change in resting metabolic rate required to distinguish true physiological change from measurement variability.
Time frame
12 weeks2
Between-Individual Variability in RMR
Assessment of variability in resting metabolic rate between participants based on repeated measurements.
Time frame
12 weeks3
Temporal Trends in RMR
Assessment of systematic changes in resting metabolic rate over time using repeated measurements across the study period.
Time frame
12 weeksSponsors and contacts
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Source ClinicalTrials.gov