The purpose of this study is to test whether a special memory training program, called CogMed, can help people with early memory problems. The Investigators want to see if this training improves memory and also helps reduce stress.
The Investigators also want to see if CogMed results in changes to a blood biomarker called p-Tau 217, which possibly indicate Alzheimer's disease (AD).
Male or female outpatients ages ≥ 50 years;
Meet Mayo Clinic Criteria for MCI. (Patients with mild cognitive impairment)
Access to the internet through computer
A proficiency in speaking and reading English or having a family member who is proficient in reading and speaking English and is willing to serve as a translator.
Mini Mental State Exam (MMSE) score less than 19 or patients diagnosed with moderate or severe dementia by a clinician.
In the opinion of the investigator, participation would not be in the best interest of the subject.
Parallel
CogMed
Other interventionCogMed which is a computerized working memory training program developed by Karolinska University.
Working Memory as measured by the WAIS-IV Digit Span Forward/Backward
The Digit Span Forward/Backward is a subset of the Wechsler Adult Intelligence Scale (WAIS) that captures attention efficiency and working memory.
Working Memory as measured by the TMT-B
The Trail Making Test (TMT) is a well-established test sensitive to impairment in multiple cognitive domains.
Working Memory as measured by Category Fluency Test
The Category Fluency Test (CFT) was created to assess semantic fluency. It consists of asking the individual to name as many animals as possible in 60 s. Performance on CFT can be evaluated through several components, such as the number of correct words, clusters, switching, related words, and intrusion and perseveration errors.
Change in Blood biomarker
We do not expect a significant change in p-Tau 217 during the short-proposed study duration, however, we projected that we will successfully recruit 10 MCI patients (Intervention group = N 5; and control group (N=5) that will be willing to undergo blood draw for determination of p-Tau 217 level.
Perceived Stress Scale (PSS) Score
The Perceived Stress Scale (PSS) is used for measuring the perception of stress. It is a measure of the degree to which situations in one's life are appraised as stressful. The scale also includes questions about current levels of experienced stress (Cohen et al, 1983).
Brief Resilience Scale (BRS) Score
The Brief Resilience Scale (BRS) has 6 items and is a reliable means of assessing resilience as the ability to bounce back or recover from stress (Smith et al., 2008).
Pittsburgh Sleep Quality Index (PSQI) Score
The Pittsburgh Sleep Quality Index (PSQI) is a self-rated questionnaire designed to measure sleep quality and disturbance over past month (Buysse et al.,1989).
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St. Joseph's Hospital and Medical Center, Phoenix
Lead sponsor
Barrow Neurological Foundation
Collaborator
Barrow Neurological Institute
Collaborator
