Wuhan High Myopia Study
ConditionHigh Myopia
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-65
SponsorRenmin Hospital of Wuhan University
About this trial
The study aims to observe the long-term changes of ocular（especially fundus） structure and visual function in patients with high myopia, so as to provide evidence for the prevention, diagnosis and prognosis of high myopia.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Voluntarily sign informed consent;
Commit to follow the research procedures and cooperate with the whole process of the study;
Age ≥18 years old;
Best corrected visual acuity ≥0.1;
Disqualifiers
Unable or unwilling to sign informed consent;
Unable to cooperate with the examination;
Astigmatism ≤-1.5D；
Patients with refractive interstitial opacity so that fundus images cannot be collected；
Trial population
First-year college student from Wuhan University
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
observational
Other interventionnone (observational study)
Treatment groups
1,000 Participants
are divided into 1 treatment groupGroup A: entire cohort1 intervention
Trial outcomes
Primary outcomes
1
Myopic optic nerve changes
Changes in the optic nerve head morphology and blood supply which are supposed to be related with high myopia，examined by fundus photography，OCT，OCTA，etc
Time frame
Baseline and 6 months and 1，2,3,4years2
Progression of axial length (AL)
Subjects' axial length and its progression collected by IOL master 700
Time frame
Baseline and 6 months and 1，2,3,4years3
Incidence and progression of visual field (VF) defects
Variety and progression of visual field defects collected by Humphrey 860 perimetry
Time frame
Baseline and 6 months and 1，2,3,4years4
Loss of best corrected visual acuity（BCVA）
Incidence of BCVA loss collected by subjective optometry
Time frame
Baseline and 6 months and 1，2,3,4yearsSecondary outcomes
1
Relationship between the changes of visual function and pathological changes among patients with high myopia
Relationship between the changes of visual function including best corrected visual acuity and visual field and pathological changes among patients with high myopia
Time frame
Baseline and 6 months and 1，2,3,4years2
Structural parameters of anterior segment
Structural parameters of anterior segment including corneal curvature，lens thickness(LT)，etc
Time frame
Baseline and 6 months and 1，2,3,4years3
Intraocular pressure(IOP)
Incidence of elevated intraocular pressure collected by a non-contact tonometer
Time frame
Baseline and 6 months and 1，2,3,4years4
Mental state and quality of life
Mental state and quality of life collected by a questionnaire
Time frame
Baseline and 6 months and 1，2,3,4yearsSponsors and contacts
Click on the lead sponsor to view all of their trials.
Source ClinicalTrials.gov