The goal of this observational study is to learn about social cognition and risky behaviour in patients with young-onset dementia (YOD). The investigators want to
* Examine differences in performance on social cognition test and measures of risky behaviour between behavioural variant YOD patients, patients with frontal brain injury, non-behavioural YOD patients and healthy controls. * Examine if there is a relation between social cognition tests and measures of risky behaviour.
Participants will be administered a neuropsychological assessment including social cognition measures and patients will complete a driving simulator task in which risky behaviour will be elicited.
Sufficient command of the Dutch language
In possession of a driver's license with any driving experience throughout life
Age 18 to 65
Probable diagnosis of young-onset dementia (before 65 years old), confirmed after interdisciplinary consensus meeting in which interviews, neuropsychological examination, neurological and psychiatric assessments, neuro-imaging, blood samples, and in some cases FDG/PIB-PETscans, CSF biomarkers or genetic counseling were discussed.
Suffering from severe motion sickness; motion sickness is a risk factor for simulator sickness
Presence of serious psychiatric disorders
History of neurological disorders, which may interfere with cognitive functioning (e.g. recent concussion, previous subarachnoid or intracerebral haemorrhage, intracranial tumours, epilepsy, ischemic stroke).
Patients with young-onset dementia, i.e. onset of dementia before the age of 65 years.
Case-control
Cross-sectional
Neuropsychological assessment, driving simulator task
Other interventionNeuropsychological assessment consisting of test measuring general cognitive abilities and social cognition. Driving simulator task measuring risk-taking.
Social cognitive performance
Social cognition in bvYOD, compared to non-bvYOD, patients with frontal brain injury and healthy controls
Association between social cognition and risky decision-making
Association between several aspect of social cognition (i.e. emotion recognition, empathy, theory of mind, emotion experience) and risk-taking behaviour.
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University Medical Center Groningen
Lead sponsor
ZonMw: The Netherlands Organisation for Health Research and Development
Collaborator
This trial is not recruiting at the moment. You can still explore other options:
