Young Onset Parkinson's Disease Subtypes and Pathogenic Mechanisms
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorNYU Langone Health
About this trial
Young Onset Parkinson's disease (YOPD) refers to a group of patients in which the disease starts earlier in life (before the age of 50 years) and has a profound impact on most of patient's life. Current knowledge regarding the mechanisms leading to development of Parkinson's disease in younger individuals is lacking, but their understanding is crucial for the successful design of therapeutic strategies and stratifying patients for clinical trials. With this research the investigators aim to clarify the contribution of relevant biological processes in patients with Young onset Parkinson's disease to help understanding disease mechanisms and biomarkers.
Eligibility criteria
Qualifiers
Male or female 18 years or older (inclusive) of any race and ethnicity
Diagnosis of Parkinson's disease (PD) confirmed by a movement disorder specialist and with an age of onset of less than or equal to the age of 50 years old
Willingness to undergo a skin punch biopsy
Male or female 18 years or older (inclusive) of any race and ethnicity
Disqualifiers
Diagnosis of atypical parkinsonism (i.e. progressive supranuclear palsy, corticobasal degeneration, multiple system atrophy) or secondary parkinsonism (i.e. normal pressure hydrocephalus, drug-induced parkinsonism).
Clinical history of autoimmune or chronic inflammatory disorder or exposure to chronic immunosuppressant or immunomodulatory medications.
Pregnancy
Dermatological conditions that would prevent performing skin punch biopsies
Trial design
Treatments tested in this trial
- Not listed
Trial groups
250 Participants
are grouped into 3 trial groupsSponsors and collaborators
NYU Langone Health
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
Collaborator
Source ClinicalTrials.gov