Zinc and Iron Absorption From Common Beans in Young Adult Women
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
Age19-24
SponsorUniversity of California, Davis
About this trial
Fifteen female study participants will be enrolled in a randomized crossover study to measure fractional and total zinc and iron absorption from four common bean (Phaseolus vulgaris) varieties with varying phytate and polyphenolic contents. Phytate, the storage form of phosphorus in plants, and polyphenols, which contribute to the varied colors of common beans, are natural components of the beans and can reduce zinc and iron bioavailability from these foods.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Healthy eumenorrheic (regular monthly menstrual cycles of 25-30-days in length)
BMI 18.5 - 30 kg/m2
Regular consumer of beans, i.e. ≥ 4 servings per month
Usual iron intake estimated by Food Frequency Questionnaire to be less than the Recommended Daily Allowance (RDA) of 18 mg/d (8)
Disqualifiers
Dislike or allergy to beans
Self-reported current or recent pregnancy (within the past 12 months)
Self-reported recent termination of pregnancy (3 months if abortion in 1st or 2nd trimester, or 12 months if in 3rd trimester)
Self-reported plans to become pregnant during the study period
Trial design
Design model
Crossover
Treatments tested in this trial
SER 118
Other interventionBean High in Phytic Acid and High in Inhibitory Polyphenols
LMP 1001
Other interventionBean Low in Phytic Acid and High in Inhibitory Polyphenols
LPA 586
Other interventionBean Low in Phytic Acid and Low in Inhibitory Polyphenols
KAT B1
Other interventionBean High in Phytic Acid and Low in Inhibitory Polyphenols
Treatment groups
15 Participants
are divided into 4 treatment groupsGroup A: Bean Variety 1Experimental treatment 1 intervention
Group B: Bean Variety 2Experimental treatment 1 intervention
Group C: Bean Variety 3Experimental treatment 1 intervention
Group D: Bean Variety 4Experimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
Fractional Zinc absorption
amount of zinc absorbed and circulating in blood
Time frame
24 hours after first intake2
Fractional Iron absorption
amount of iron absorbed and circulating in the blood
Time frame
24 hours after first intakeSecondary outcomes
1
Total Zinc absorption
total amount of zinc absorbed from meals
Time frame
24 hours after first intake2
Total Iron absorption
total amount of iron absorbed from meals
Time frame
24 hours after first intakeSponsors and contacts
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Source ClinicalTrials.gov