ACL - Anterior Cruciate Ligament Deficiency

3

Review clinical trials related to ACL - Anterior Cruciate Ligament Deficiency. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

AI-Based Video Assessment of Anterior Knee Laxity

This prospective observational validation study aims to evaluate the accuracy and reliability of artificial intelligence-based video analysis for quantifying anterior knee laxity. Participants with unilateral anterior cruciate ligament (ACL) injury and ACL-intact controls will undergo bilateral knee examination using a Rolimeter by two independent orthopedic surgeons. Three consecutive measurements will be obtained for each knee and examiner. Each examination maneuver will be video recorded using a standardized acquisition protocol including a metric reference of known dimensions. The videos will subsequently be analyzed independently by a multimodal artificial intelligence system blinded to clinical diagnosis, MRI findings, injured side, examiner measurements, and contralateral knee measurements. AI-derived anterior tibial translation and side-to-side difference will be compared with Rolimeter measurements. The primary objective is to assess agreement between AI-derived and Rolimeter-derived side-to-side difference. Secondary objectives include inter-examiner reliability, AI repeatability and the diagnostic accuracy of AI-derived measurements for identifying ACL injury.

Participants needed: 70
Trial details
Age: 16-55Biological sex: AllType: ObservationalSponsor: ASL LecceUpdated: Sep 22, 2026Locations: 1
Eligibility criteria

General inclusion criteria [+10]

Previous ACL reconstruction or other major ligament reconstruction of either kne... [+9]

Status: Recruiting

5 Years' Follow-up Assessment of Surgical Repair for ACL Proximal Rupture

Isolated ruptures of ACL (anterior cruciate ligament) are ligament injuries that can be proximal, central or distal. Treatment of patients with proximal lesions should be graded. Functional treatment can be reserved for low-demanding patients in whom the practice level is limited and progression risk to a functionally unstable knee less marked. In athletes, the risk of a new sprain must be explained and the patient will choose functional treatment or surgical treatment. Surgical treatment generally involves ligamentoplasty at the expense of a knee tendon to replace the ruptured ACL. In the context of proximal ACL rupture, the patient can be offered surgical repair of the ACL. There are numerous studies on ACL ligamentoplasties results but literature is poor on modern ACL repair outcomes. In this context, this study aims to describe the relapse rate at 5 years of patients operated for a proximal ACL tear.

Participants needed: 150
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: GCS Ramsay Santé pour l'Enseignement et la RechercheUpdated: Aug 20, 2026Locations: 1
Eligibility criteria

Patient, male or female, aged ≥ 18 years [+6]

Patient with contralateral ACL tear [+2]

Status: Recruiting

Comparison of Surgical Repair Versus Functional Treatment in Patients With Proximal ACL Tear

Isolated ruptures of the anterior cruciate ligament (ACL) can be proximal, distal or occur in the middle of the ACL. Treatment of patients with proximal lesions should be graded. Functional treatment can be reserved for low-demanding patients in whom the practice level is limited and the risk of progression to a knee functionally unstable less marked. In athletes, the risk of a new sprain must be explained and the patient will choose a functional treatment or a surgical treatment. Few studies exist in the literature on the superiority of surgical treatment compared to functional treatment. In this context, this study is based on the hypothesis that patients undergoing ACL surgical repair have better functional scores and more intense sport activity than patients with functional treatment.

Participants needed: 144
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: GCS Ramsay Santé pour l'Enseignement et la RechercheUpdated: Aug 20, 2026Locations: 1
Eligibility criteria

Patient, male or female, aged ≥ 18 years [+5]

Patient with contralateral ACL tear [+5]