Active Refractory Rheumatoid Arthritis

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Review clinical trials related to Active Refractory Rheumatoid Arthritis. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

A Phase 2 Master Protocol Assessing Inebilizumab and Blinatumomab in Autoimmune Diseases

The main objective is to assess the safety and tolerability of inebilizumab in adult participants with active and refractory systemic lupus erythematosus (SLE) with nephritis (Subprotocol A) and to assess the safety and tolerability of subcutaneous (SC) blinatumomab in adult participants with active and refractory SLE with and without nephritis (Subprotocol B Part A) and in adult participants with active refractory rheumatoid arthritis (RA) (Subprotocol C Part A). The trial will also assess the efficacy of SC blinatumomab in adult participants with active and refractory SLE with and without nephritis (Subprotocol B Part B and Subprotocol C Part B).

Participants needed: 220
Trial details
Phase: Phase 2Age: 18-75Biological sex: AllType: InterventionalSponsor: AmgenUpdated: Aug 21, 2026Locations: 58
Eligibility criteria

Subprotocol A and B: Diagnosis of SLE according to 2019 European League Against... [+23]

Subprotocol A, B and C: Receipt of a live and/or live attenuated vaccine within... [+15]