Status: Not yet recruiting
De-EscaLaTion of Aromatase Inhibitor Therapy: A Randomized Phase II Study of De-escalated Letrozole in Hormone Receptor-Positive Early Breast Cancer
This study is a randomized, open-label, phase II trial designed to evaluate whether alternate-day dosing of letrozole preserves antiproliferative activity compared with standard daily dosing in postmenopausal women with estrogen receptor-positive, HER2-negative breast cancer.
Participants needed: 144
Trial details
Phase: Phase 2Age: 18-59Biological sex: FemaleType: InterventionalSponsor: Montefiore Medical CenterUpdated: Oct 8, 2026Locations: 1
Eligibility criteria
Participants must have histologically confirmed breast cancer, clinical stage I-... [+4]