Status: Recruiting
Brain Metastases in Greater Size - Hypofractionated Options Trial (BIGSHOT)
This is a randomized, phase II trial comparing staged stereotactic radiosurgery (SSRS) versus fractionated stereotactic radiotherapy (FSRT) in patients with large brain metastases (≥2 cm and ≤5 cm). The study aims to evaluate efficacy, safety, and tumor response between these two standard-of-care radiation approaches.
Participants needed: 54
Trial details
Phase: Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: Medical University of South CarolinaUpdated: Sep 18, 2026Locations: 1
Eligibility criteria
The patient or a legally authorized representative must be able and willing to p... [+12]
Prior cranial radiotherapy, including whole brain radiotherapy (WBRT), or SRS in... [+3]