Central Centrifugal Cicatricial Alopecia (CCCA)

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Review clinical trials related to Central Centrifugal Cicatricial Alopecia (CCCA). Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

Tirzepatide for Treatment of CCCA

The goal of this pilot clinical trial is to learn if tirzepatide can treat active central centrifugal cicatricial alopecia (CCCA), a type of permanent scarring hair loss, in adults. The main questions it aims to answer are: * Does tirzepatide improve the symptoms and signs of active CCCA? * Does tirzepatide change the activity of genes in the scalp, especially genes related to scarring? * Does tirzepatide promote hair regrowth? Participants will: * Inject tirzepatide once a week for 12 months. * Visit the clinic for scalp examinations, photographs, and other health assessments. * Have scalp biopsies at the beginning of the study and after 6 months of treatment. * Have blood tests and other safety monitoring during the study. There is no separate comparison group. Researchers will compare each participant's results during treatment with the participant's results at the beginning of the study.

Participants needed: 20
Trial details
Phase: Phase 2Age: 18-80Biological sex: AllType: InterventionalSponsor: Johns Hopkins UniversityUpdated: Aug 12, 2026Locations: 2
Eligibility criteria

Age 18 to 80 years. [+5]

Currently taking an oral or systemic blood glucose-lowering medication. [+20]

Status: Recruiting

Treatment Results for Patients With Central Centrifugal Cicatricial Alopecia (CCCA): a Multicenter Prospective Study

The objective of this study is to examine photos of CCCA patients taken before and after treatment to compare treatment outcomes between different treatment groups

Participants needed: 250
Trial details
Phase: Phase 4Age: 18-60Biological sex: FemaleType: InterventionalSponsor: Wake Forest University Health SciencesUpdated: Mar 31, 2026Locations: 1
Eligibility criteria

African-American women, ages 18-60 years old [+2]

Patients with other forms of hair loss in addition to CCCA will be excluded [+4]