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Chronic Pruritus of Unknown Origin

3

Review clinical trials related to Chronic Pruritus of Unknown Origin. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

A Study to Evaluate Efficacy, Safety, and Tolerability of Remibrutinib in Adult Participants With Severe Chronic Pruritus of Unknown Origin (CPUO)

The purpose of this phase 3 study is to establish the efficacy, safety and tolerability of remibrutinib in adult participants with severe chronic pruritus of unknown origin (CPUO).

Participants needed: 180
Trial details
Phase: Phase 3Age: 18+Biological sex: AllType: InterventionalSponsor: Novartis PharmaceuticalsUpdated: Oct 13, 2026Locations: 7
Eligibility criteria

Participant must be ≥ 18 years of age, at the time of signing the informed conse... [+8]

Any active skin conditions (e.g., atopic dermatitis, psoriasis, etc.) that may i... [+5]

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Status: Recruiting

A Study to Evaluate Efficacy, Safety and Tolerability of Remibrutinib in Adult Participants With Severe Chronic Pruritus of Unknown Origin (CPUO)

The purpose of this phase 3 study is to establish the efficacy, safety and tolerability of remibrutinib in adult participants with severe chronic pruritus of unknown origin (CPUO).

Participants needed: 180
Trial details
Phase: Phase 3Age: 18+Biological sex: AllType: InterventionalSponsor: Novartis PharmaceuticalsUpdated: Oct 13, 2026Locations: 17
Eligibility criteria

Participant must be ≥ 18 years of age, at the time of signing the informed conse... [+8]

Any active skin conditions (e.g., atopic dermatitis, psoriasis, etc.) that may i... [+5]

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Status: Not yet recruiting

Efficacy and Safety of ATTO-1310 in the Treatment of Participants With Chronic Pruritus of Unknown Origin

The goal of this clinical trial is to assess the efficacy and safety of ATTO-1310 in patients with chronic pruritus/itch of unknown origin. The main questions it aims to answer are: Does ATTO-1310 treatment alleviate symptoms of itch in participants with chronic pruritus/itch? What medical problems do participants have when taking ATTO-1310 for 24 weeks? Researchers will compare ATTO-1310 to a placebo (a look-alike substance that contains no drug). Participants will be dosed with ATTO-1310 or a placebo, visit the clinic for checkups and tests, and keep a diary of their symptoms.

Participants needed: 300
Trial details
Phase: Phase 2Age: 18-90Biological sex: AllType: InterventionalSponsor: Attovia Therapeutics IncUpdated: Sep 22, 2026
Eligibility criteria

Aged 18 to 90 years with a body weight of 50 to 125 kg and body mass index (BMI)... [+7]

Known condition, other than dry skin, that is considered by the Investigator to... [+11]

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