Corneal Transplantation

4

Review clinical trials related to Corneal Transplantation. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Factors Influencing Corneal Donation in Palliative Care Unit

Today, there is a shortage of tissues such as corneas for a variety of reasons. However, it is possible to harvest tissues from people who are usually excluded from donation, particularly cancer diagnosed, by recruiting them into palliative care units. Corneal transplantation is a surgical procedure designed to improve the vision of many persons. A number of diseases now require corneal transplants, such as keratoconus. As with other organs, the shortage of donors remains a major obstacle to the use of this technique, a shortage which became much more acute during the health crisis linked to the pandemic caused by the SARS-CoV-2 virus. In 2022, 10615 participants were waiting for a transplant, but only 46.3% of them received one. Cornea removal differs from the removal of other organs. Firstly, there are fewer contra-indications. It can be performed on persons with chronic conditions that would usually exclude them from receiving other organs, such as cancer. As the cornea is not vascularised, the risk of damage is considered to be zero, except in cases of cancers of cerebral neurological origin or melanoma. Secondly, the donor's remains can be preserved for up to 24 hours after death. This makes it possible to recruit care services that are not usually involved in organ transplants, as these services provide new potential donor recruitment resources. This includes palliative care units. There is currently no French literature on corneal donation specifically in palliative care units. There is a lack of data on the factors that encourage or hinder donation. Based on our experience of corneal donation in our palliative care unit since 2020, the investigators are conducting a clinical study to evaluate the factors that facilitate or impede corneal donation in our hospital palliative care unit.

Participants needed: 150
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Groupe Hospitalier Diaconesses Croix Saint-SimonUpdated: Oct 9, 2026Locations: 1
Eligibility criteria

Relative or confidant over 18 years of age. [+2]

Confidant person who does not speak or read French. [+2]

Status: Recruiting

The German Keratoplasty Registry of the German Ophthalmological Society (DOG)

Aim of this study is to reflect on the changing trends in absolute numbers, surgical techniques and indications of corneal transplantations being performed in Germany. The Section Cornea of the German Ophthalmological Society provides interim-assessments on a regular basis about the most up-to-date results of this long-term study.

Participants needed: 100,000
Trial details
Age: 1-100Biological sex: AllType: ObservationalSponsor: Universität des SaarlandesUpdated: Apr 27, 2026Locations: 1Duration: 16 Years
Eligibility criteria

Not listed

Status: Not yet recruiting

Intraoperative Optical Coherence Tomography for Ophthalmic Surgical Guidance - Cornea

Optical Coherence Tomography (OCT) image data will be evaluated for image quality and used to test post-processing algorithms to improve detection sensitivity for ophthalmic diseases.

Participants needed: 24
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Vanderbilt University Medical CenterUpdated: Mar 16, 2026Locations: 1
Eligibility criteria

Adults (>18 years) with diagnosis of cornea transplant (keratoplasty)

Children or adults unable to consent [+1]

Status: Recruiting

Pretreatment to Promote Graft Survival After Subsequent High-risk Corneal Transplantation [CrossCornealVision]

The trial evaluates the effect of corneal crosslinking as pre-treatment before corneal transplantation. The goal is to improve graft survival by reducing pathological vessels through pre-treatment.

Participants needed: 110
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Claus CursiefenUpdated: Oct 21, 2024Locations: 7
Eligibility criteria

Written informed consent by subject and/or witness prior to any study-related pr... [+6]

< 2 corneal quadrants covered by pathological neovascularization [+18]