Dental Anesthesia

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Review clinical trials related to Dental Anesthesia. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Efficacy of Pre-cooling and Sweet-tasting Solution on Pain Related to Local Anesthesia Injection in Children

The study aims to determine whether pre-cooling and sweet-tasting solutions, alone or combined with topical anesthesia, provide better pain control during dental local anesthesia in children. It has two phases: Phase 1: Identify the children's preferred sweet-tasting solution among xylitol, monk fruit, erythritol, and honey. Phase 2: A randomized controlled trial comparing 7 groups involving pre-cooling, sweet solution, topical anesthesia, and their combinations. The primary outcome is pain measured by VAS, while secondary outcomes include SEM behavioral response, heart rate, and oxygen saturation. The planned sample is 220 children.

Participants needed: 224
Trial details
Age: 7-11Biological sex: AllType: InterventionalSponsor: British University In EgyptUpdated: Sep 22, 2026Locations: 1
Eligibility criteria

Age group 7-11 years [+2]

Failure to provide assent or consent [+3]

Status: Not yet recruiting

MRI and Local Anesthesia

The purpose of this research is to investigate the utility of using dental-dedicated MRI as a measurement tool to observe and evaluate the administration of local anesthesia in dental patients.

Participants needed: 102
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: University of MinnesotaUpdated: Sep 10, 2026Locations: 1
Eligibility criteria

Adult age 18 or older [+3]

ASA class 3 or higher [+11]

Status: Not yet recruiting

Melissa Officinalis Aromatherapy for Dental Anxiety in Children

This clinical study will look at whether a plant-based essential oil called "Melissa officinalis" (lemon balm) can help reduce fear and stress in children during dental treatment. Children between 6 and 10 years old who need a mandibular injection for a pulpotomy or pulpectomy will be invited to participate. They will be randomly assigned to one of three groups: one group will receive aromatherapy with \*Melissa officinalis\* from brand A, another group will receive the same essential oil from brand B, and a third group will receive the usual behavioral management used in pediatric dentistry, but without aromatherapy. The essential oil will be diffused in the dental room so that the child can gently inhale the aroma starting a few minutes before the injection and throughout the procedure. The study team will measure the child's dental anxiety using a child-friendly questionnaire with drawings of faces, observe pain behaviors during the injection, and record the child's own rating of pain with a faces scale. Heart rate and oxygen saturation will also be monitored as objective signs of stress. The goal is to find out whether "Melissa officinalis" aromatherapy is a safe, simple, non-invasive way to make dental visits less stressful and more comfortable for children, and whether there are meaningful differences between the two commercial products.

Participants needed: 45
Trial details
Phase: Phase 2Age: 6-10Biological sex: AllType: InterventionalSponsor: Universidad Autonoma de San Luis PotosíUpdated: May 18, 2026
Eligibility criteria

Children aged 6 to 10 years at the time of enrollment. [+7]

History of previous dental local anesthesia. [+9]

Status: Not yet recruiting

"Study of Pain Perception Using Computer-Controlled Versus Conventional Local Anaesthesia in Children Undergoing Molar Extraction

This clinical trial aims to compare pain perception in children during dental procedures when using a computer-controlled local anesthesia device versus a traditional syringe. Children aged 6 to 8 years who need maxillary primary molar extraction will be randomly assigned to one of four groups: three groups using different speeds of the GENI computer-controlled device, and one group using a conventional syringe. The study will assess pain using facial expression scales and physiological measures such as heart rate. The goal is to find a more comfortable method for delivering anesthesia to pediatric dental patients.

Participants needed: 76
Trial details
Age: 6-8Biological sex: AllType: InterventionalSponsor: Tarek MHD kher al saka aminiUpdated: Jul 14, 2025Locations: 1
Eligibility criteria

Children aged from 6 to 8 years old [+6]

Uncooperative children or those with a behavioral management problem (Frankl rat... [+4]