Dependence Addictive

2

Review clinical trials related to Dependence Addictive. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

Mobile Application-Based Interventions for Cannabis Use in Young Adults With First Episode Psychosis

Psychotic disorders affect approximately 4% of Canadians and have a significant impact on individuals' well-being, their families and social networks, and healthcare systems. The development of psychosis is explained by a complex interplay of genetic and environmental factors, including the use of psychoactive substances. Frequent cannabis use can contribute to the development of psychotic disorders. The prevalence of cannabis use disorder (CUD) in individuals with a first-episode psychosis (FEP) followed in Early Intervention Services (EIS) is 42-53%, well above that of the general population (\~3%). Cannabis use in individuals with psychosis is associated with increased symptom severity, higher rates of relapse and hospitalization, and poor psychosocial functioning. Standardized mobile app-based interventions offer a scalable and accessible solution. Our team developed and piloted CHAMPS (harm reduction) and iCanChange (use reduction/cessation) with favourable results: retention 82% (CHAMPS) and 84-86% (iCC), high satisfaction, and preliminary efficacy signals. The two pilot studies were targeting feasibility, this study is studying efficacy of the two app-based interventions (CHAMPS and iCanChange).

Participants needed: 550
Trial details
Age: 18-35Biological sex: AllType: InterventionalSponsor: Centre hospitalier de l'Université de Montréal (CHUM)Updated: Sep 10, 2026
Eligibility criteria

Young adults (18-35 years) with FEP [+8]

Pregnancy, breastfeeding, or any medical condition that, in the opinion of the p... [+4]

Status: Not yet recruiting

Attachment and Prognostic Factor: the Implicit Approach

This is a prospective longitudinal study aimed at better understanding the determinants of the prognosis of patients with substance dependence. 5 visits are planned during the study : * the inclusion visit : during this visit the patient's non-opposition is obtained and then the patient answer to self-administered questionnaires online * 4 telephone interviews for follow-up by investigator.

Participants needed: 200
Trial details
Age: 18-65Biological sex: AllType: ObservationalSponsor: Centre Hospitalier Henri LaboritUpdated: Jun 5, 2025
Eligibility criteria

Patients between 18 and 65 years old [+3]

Person who cannot read or write [+4]