Disability

Generation Victoria (GenV) is a longitudinal, population-based study of Victorian children and their parents that will bring together data on a wide range of conditions ,exposures and outcomes. GenV blends study-collected, study-enhanced and linked data. It will be multi-purpose, supporting observational, interventional, health services and policy research within the same cohort. It is designed to address physical, mental and social issues experienced during childhood, as well as the antecedents of a wide range of diseases of ageing. It seeks to generate translatable evidence (prediction, prevention, treatments, services) to improve future wellbeing and reduce the future disease burden of children and adults. The GenV Cohort 2020s is open to all children born over a two-year period, and their parents, residing in the state of Victoria Australia. The GenV Cohort 2020s is preceded by an Advance Cohort of children born between 5 Dec 2020 and 3 October 2021, and their parents. This comprises all families recruited at GenV's Vanguard hospital (Joan Kirner Women's and Children's) and at birthing hospitals throughout Victoria as GenV scaled up to commence recruiting for the GenV Cohort 2020s. The Advance Cohort have ongoing and full participation in GenV for their lifetime unless they withdraw but may have less complete data and biosamples.

This randomized controlled trial investigates whether adding Pain Neuroscience Education (PNE) to standard pre-operative physiotherapy improves outcomes after lumbar laminectomy. Chronic low back pain often involves central sensitization, where the nervous system continues amplifying pain signals even after the structural problem is surgically corrected, contributing to persistent neuropathic pain and disability after spine surgery. The study will enroll 44 male and female patients aged 35-60 scheduled for elective one- or two-level lumbar laminectomy, with a pre-surgical waiting period of at least three weeks. Participants will be randomized into two equal groups. The experimental group will receive a three-week "nervous system priming" program: three 45-minute sessions combining PNE (explaining pain biology and neuroplasticity through culturally adapted metaphors) with standard exercises (ankle pumps, quad sets, gluteal sets, isometric abdominal sets, heel slides, and walking), plus a home program. The control group will receive identical standard exercises and session structure, but without PNE, using placebo counselling instead. Outcomes will be measured using the painDETECT questionnaire (neuropathic pain) and the Oswestry Disability Index (functional disability), assessed at baseline, three weeks post-operatively, and three months post-operatively. The study will run for seven months following ethical approval. The research addresses a gap in current perioperative care, which is typically reactive and rarely incorporates neurophysiological education into prehabilitation. If PNE proves effective, it could reduce post-laminectomy neuropathic pain and disability, decrease dependency on painkillers and prolonged rehabilitation, and inform more effective pre-surgical protocols for spine surgery patients.

To investigate the effects of oculomotor exercises on pain disability, dizziness and gaze stability in patients with non-traumatic cervical dizziness.

Low back pain is the most common symptoms experienced by people throughout the world. Although lifetime prevalence of low back pain among women is more but it is particularly common during pregnancy, affecting approximately 50% of women. Pregnancy induces significant physiological changes, which lead to increased ligamentous laxity that may persist for 3 to 6 months postpartum. Additionally, the expanding uterus shifts the maternal center of gravity anteriorly, resulting in compensatory lumbar hyperlordosis and contributing to lower back discomfort. While these adaptations help accommodate pregnancy, they often do not fully resolve after birth, especially in the presence of abdominal muscle weakness. The result is altered posture characterized by an exaggerated lumbar lordotic curve that may predispose postpartum women to continued pain and lumbar instability. Without a structured postpartum rehabilitation program, these postural abnormalities may go uncorrected. Ensuring adherence and completion of such programs is critical for preventing long-term musculoskeletal complication. There are many efficient way to help in maintaining adherence and completion of program including the use of digital platforms. The increasing availability of low cost internet and communication technologies has enhanced the capacity to deliver healthcare services through internet, enabling broader access to physiotherapy services and follow-up care through telerehabilitation. Telerehabilitation is one of the emerging field of telemedicine, defined as set of tools, procedure, and protocols to deliver the rehabilitation process remotely. The objective of the study is to facilitate implementation of the telerehabilitation for home based program for postpartum female. The objectives of the study is to compare the effectiveness of telerehabilitation-based lumbar stability exercises versus on-site lumbar stability exercises in improving lumbar stability among postpartum female and to facilitate implementation of the telerehabilitation for home based program for postpartum female. It is a randomized controlled trial. Participants meeting the inclusion criteria will be recruited and consent form will be taken than participants will be allocated to group A (On-Site Lumbar Stability exercise) and B (Telerehabilitation) through 1:1 method. Pre-treatment assessment will be carried out on Day 1 using the outcome measures tool like NPRS, ODI and LLA. Participant will receive intervention for 6 weeks, 3 sessions per weeks. After the completion, on 6 week Post-treatment assessment will be carried out using the same outcome measures tool like NPRS, ODI and LLA.

1. Identify the primary risk factors for disability in older adults through multi-dimensional risk factor screening. 2. Develop a risk stratification model for disability in older adults by integrating outcome indicators and temporal characteristics, and construct an intelligent early warning model to enable automated assessment and monitoring of disability risk. 3. Establish key digital technologies for early warning and prevention of disability risk in older adults, and develop a whole-process digital intervention platform incorporating a decision support system for disability prevention management. 4. Create a digitally empowered hospital-community-household collaborative system for precise assessment and intervention of disability risk in older adults, achieving data-driven whole-process active disability management. The system will be demonstrated and evaluated in communities with diverse characteristics across urban, county, and rural settings.

MN RETAIN Phase 3 is a non-randomized trial to evaluate the impact of RETAIN program expansion and services on workforce retention and reduction of future workplace disability in the state of MN. The program is funded by US Department of Education (DOE). There will be collaboration between partners to implement best practices in early intervention to support injured or ill employees in stay-at-work and return-to-work. MN RETAIN involves a partnership between Mayo Clinic and MN Department of Employment and Economic Development (DEED), and stakeholders throughout MN. MN DEED serves as the main recipient and administrator of the funding within the state with Mayo Clinic a subrecipients of the grant.

The goal of this observational study is to establish the prospective cohort of the Beijing Longitudinal Disability Survey in Community Elderly (BLINDSCE) to explore the high-risk factors and preventive interventions for disability and cognitive impairment among community-dwelling adults aged 65 years and over. The main question it aims to answer is: * What are the high-risk factors able to predict the incidence and advance of disability and cognitive impairment in community-dwelling adults aged 65 years and over? * What are the categories of function and cognitive performance trajectory in community-dwelling adults aged 65 years and over?

This is a community-based prospective cohort study in China. The study has been initialized in 2024 and included older residents. The goal of this observational study is to explore the risk factors related to disability and dementia in the elderly Chinese community population, and develop a risk prediction model for disability and dementia.

This is a community-based prospective cohort study in Beijing, China. The study has been initialized in 2023 and enrolled older residents. This study aims to develop disability risk assessment standards and an early warning model for older adults.

This project aims at studying the evolution of masticatory function (food bolus granulometry, masticatory behavior, muscle activity and masticatory performance) during oral rehabilitation, in children with different types of oral health impairment. Secondary objectives are to study the relationships between children masticatory function (food bolus granulometry, masticatory behavior, muscle activity and masticatory performance) and its evolution during oral rehabilitation, and: * their type of oral health alteration * their eating behaviors * their height and weight status During examination the following parameters are collected: * Various clinical indicators of oral health * The child's weight and height * Frequency and nature of orofacial dysfunctions * The oral health related quality of life of children and their families * Chewing tests are performed (chewing gum, natural food such as carrot, cereals, and cheese samples, samples of gelatins of different hardness) Examination and differents tests are performed every six months for a total of 5 years (per participant) The dental care procedures performed during the study were carried out in the usual way.