Fatigue, Mental

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Review clinical trials related to Fatigue, Mental. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

Single Arm, Monocentric, Pilot Feasibility Study on an Interactive Virtual Reality Program in 20 Complex In-clinic Palliative Care Patients

Palliative care patients frequently face a "symptom cluster" of pain (up to 96%), fatigue (up to 90%), and anxiety (up to 79%), which severely degrades their quality of life in their final months.The study is built on the concept of passive exposure therapy (VREP), which engages multiple senses to distract the brain from pain signals. By creating an "immersive distraction" or a "flow state," VR can activate the brain's reward networks and reduce activity in areas associated with pain perception. Unlike most existing VR research in palliative care which uses "passive" VR (like watching a 360-degree video), this study uses interactive VR. Patients can perform simple actions-like grabbing or dropping virtual objects-within a calming natural environment, which may better support their sense of autonomy and dignity. Because this is a pilot study, the "Go/No-Go" decision for future larger trials depends on a strict composite of three factors: * Adherence: The patient must complete at least 11 out of 14 planned daily sessions. * Duration: Each session must average at least 7.5 minutes of usable VR exposure. * Tolerance: The patient must experience no device-related serious adverse events and maintain a high average tolerance score (VRISE score ≥ 25).

Participants needed: 20
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: University Hospital, Strasbourg, FranceUpdated: Apr 22, 2026Locations: 1
Eligibility criteria

Patient ≥ 18 years old, hospitalized at the USP - HUS [+6]

Patients with psychiatric disease [+3]

Status: Recruiting

Monitoring Fatigue In Daily Life In Adults With Cerebral Palsy or Acquired Brain Injury

The goal of this observational study is to learn about levels and patterns of fatigue in adults with cerebral palsy (CP) and acquired brain injury (ABI) in daily life. The main question it aims to answer is: How do adults with CP and ABI experience fatigue in daily life? Researchers will compare data from CP and ABI with healthy volunteers to see if they experience fatigue differently. Participants will: * Monitor their symptoms, mood, and behavior in real-time by completing a brief survey on their mobile phone 10 times a day for seven consecutive days. * Attend a briefing session the day prior to the seven-day period of real-time monitoring. * Wear an accelerometer for the seven-day period. * Complete a daily sleep diary for the seven-day period. * Receive feedback on their real-time monitoring data, sleep and activity data.

Participants needed: 120
Trial details
Age: 30-65Biological sex: AllType: ObservationalSponsor: Rigshospitalet, DenmarkUpdated: Aug 22, 2025Locations: 1
Eligibility criteria

Score of minimum 4 on the 7-item Fatigue Severity Scale (CP and ABI only) [+10]

History of other neurological disorders or chronic fatigue syndrome requiring tr... [+2]