Health Trials

Fuchs

3

Review clinical trials related to Fuchs. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Descemet Endothelial Thickness Comparison Trial II

Descemet Endothelial Thickness Comparison Trial (DETECT) II is a multi-center, outcome assessor-masked, placebo-controlled clinical trial randomizing 60 patients with Fuchs endothelial dystrophy to DMEK versus Descemet Stripping Only (DSO) with adjunctive Ripasudil.

Participants needed: 60
Trial details
Phase: Phase 3Age: 18+Biological sex: AllType: InterventionalSponsor: Stanford UniversityUpdated: Aug 17, 2026Locations: 8
Eligibility criteria

Dysfunctional endothelium from FECD with few guttata extending beyond 4.5 mm [+4]

Aphakia, anterior chamber IOL or scleral fixated IOL in study eye prior to or an... [+9]

Read more
Status: Not yet recruiting

Study of EO2002 in Subjects With Corneal Edema Secondary to Corneal Endothelial Dysfunction

This study will evaluate the safety and effectiveness of a single injection of EO2002 at one of two dose levels (150,000 or 500,000 magnetic human corneal endothelial cells \[mHCECs\]), compared with a placebo injection, in participants with corneal edema caused by corneal endothelial dysfunction.

Participants needed: 121
Trial details
Phase: Phase 2Age: 21+Biological sex: AllType: InterventionalSponsor: EmmecellUpdated: Jul 29, 2026Locations: 1
Eligibility criteria

Symptomatic central corneal edema that is primarily responsible for loss of visi... [+4]

Corneal disease in either eye (other than corneal endothelial dysfunction second... [+9]

Read more
Status: Recruiting

DT-168 in Keratoplasty Patients With Fuchs Endothelial Corneal Dystrophy

The purpose of this study is to evaluate the pharmacodynamics, safety, and tolerability of DT-168 Ophthalmic Solution in pre-keratoplasty patients with Fuchs endothelial corneal dystrophy.

Participants needed: 28
Trial details
Phase: Phase 2Age: 30+Biological sex: AllType: InterventionalSponsor: Design Therapeutics, Inc.Updated: Dec 29, 2025Locations: 2
Eligibility criteria

Participant is scheduled to undergo a keratoplasty for management of FECD indepe... [+4]

Any ocular or medical condition in the study eligible eye which is clinically si... [+9]

Read more