High Risk Smoldering Multiple Myeloma (HR-SMM)

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Review clinical trials related to High Risk Smoldering Multiple Myeloma (HR-SMM). Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

A Study to Compare Linvoseltamab and Daratumumab Treatment in High-Risk Smoldering Multiple Myeloma (HR-SMM)

This study is researching an experimental drug called linvoseltamab (also called "study drug") compared to another drug called daratumumab, in participants with Smoldering Multiple Myeloma (SMM), who are at a High Risk (HR) of developing active multiple myeloma. The aim of this study is to find out whether linvoseltamab is better than daratumumab in delaying the development of MM. The study is looking at several other research questions, including: * What side effects may happen from taking the study drug * How much study drug is in the blood at different times * Whether the body makes antibodies against the study drug (which could make the drug less effective or could lead to side effects)

Participants needed: 270
Trial details
Phase: Phase 3Age: 18+Biological sex: AllType: InterventionalSponsor: Regeneron PharmaceuticalsUpdated: Aug 18, 2026Locations: 3
Eligibility criteria

Eastern Cooperative Oncology Group performance status score ≤1 [+2]

Evidence of myeloma-defining events attributable to the underlying plasma cell d... [+4]