Status: Recruiting
Reversing InGuinal Hernia Trial: The Evaluation of Sex Hormones to Reverse Inguinal Hernias in Males
This is a prospective, single-center, two-arm Phase 1 safety and feasibility trial evaluating anti-estrogen therapy in men age 50 years and older with symptomatic unilateral inguinal hernias. Participants will be randomized to receive Fulvestrant 250 mg intramuscularly or anastrozole 1 mg orally for 6 months. The study will evaluate safety, tolerability, feasibility, hormone changes, hernia size, patient-reported outcomes, bone density, and imaging-based hernia classification.
Participants needed: 30
Trial details
Phase: Phase 1Age: 50+Biological sex: MaleType: InterventionalSponsor: Northwestern UniversityUpdated: Aug 3, 2026Locations: 1
Eligibility criteria
Male sex [+8]
Scrotal hernia (any) [+11]