Irreversible Pulpitis with Apical Periodontitis

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Review clinical trials related to Irreversible Pulpitis with Apical Periodontitis. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

Full Pulpotomy in Permanent Teeth With Irreversible Pulpitis and Apical Periodontitis

This study will evaluate whether full pulpotomy can successfully treat mature permanent teeth with irreversible pulp inflammation and a periapical lesion. Full pulpotomy involves removing the inflamed pulp tissue from the crown of the tooth while preserving the healthy tissue inside the roots. The study will assess pain relief, patient satisfaction, and clinical and radiographic healing over time, including healing of the periapical lesion using dental X-rays and limited-field CBCT imaging. The findings may help determine whether full pulpotomy can provide a less invasive alternative to root canal treatment for selected teeth with periapical lesions.

Participants needed: 30
Trial details
Age: 8-30Biological sex: AllType: InterventionalSponsor: King Abdullah University HospitalUpdated: Aug 17, 2026
Eligibility criteria

• Non -contributory medical history (SAI, II). [+7]

Non-restorable tooth. [+3]

Status: Not yet recruiting

Comparison of the Pain Levels of Single-Dose Premedication With Piroxicam and Prednisolone on Post-Endodontic Pain in Single-Visit Root Canal Treatment of Premolars

To compare the post operative mean pain scores by administering single-dose preoperative piroxicam and prednisolone in patients of irreversible pulpitis with symptomatic apical periodontitis.

Participants needed: 60
Trial details
Phase: Phase 4Age: 18-40Biological sex: AllType: InterventionalSponsor: RANA AHMADUpdated: Dec 15, 2025
Eligibility criteria

Healthy patient ranging between 18-40 years [+2]

History of systemic disorders including HIV, Hepatitis [+7]

Status: Not yet recruiting

To Measure Post Operative Pain Severity by Using Two Different Intra Canal Medicaments Calcium Hydroxide and Triple Antibiotic Paste in Teeth with Single Roots and Periapical Disease Called Apical Periodontitis

* The aim of this study is to compare post operative pain effectiveness between two most commonly available intra canal medicaments that are Triple Antibiotic Paste and Calcium Hydroxide during root canal treatment of single rooted teeth with symptomatic apical periodontitis. * Patients visiting OPD will be selected after fulfilment of inclusion criteria and randomly divided into two groups i.e group A patients receiving calcium hydroxide and group B with patients receiving Triple Antibiotic Paste as intra canal medicaments * Patient will be called at 48hrs 72hrs and 96hrs postoperatively. * Effectiveness of intra canal medicaments will be measured as no mild moderate severe on visual analogue scale(VAS).

Participants needed: 180
Trial details
Phase: Phase 2, Phase 3Age: 12-45Biological sex: AllType: InterventionalSponsor: Komal Ashraf KhanUpdated: Feb 12, 2025Locations: 1
Eligibility criteria

Patients of both genders having age 12-45 years [+4]

Patients who have allergies, sensitivity or unable to take medications, periodon... [+4]