Labor

5

Review clinical trials related to Labor. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

Pelvic Floor Ultrasound Before Induction of Labour and Labour Outcome

Pregnancy and vaginal birth are the main causes of pelvic floor disorders such as urinary incontinence and pelvic organ prolapse. The levator hiatus - the opening in the pelvic floor muscles through which the baby passes - can be measured on three-dimensional transperineal ultrasound at rest, during pelvic floor contraction and during a Valsalva manoeuvre. Its size and its ability to stretch have been related to how long labour lasts and to how the baby is eventually born, but the evidence comes mostly from women in spontaneous labour, in whom the exact time labour began cannot be established. Women having their labour induced offer a better model, because the time each stage of labour begins is documented. Recently, automated software has made the measurement of the levator hiatus fast and reproducible, which makes it realistic to use in everyday practice. This prospective observational study will enrol 140 women with a singleton pregnancy at 36 weeks or more who are scheduled for induction of labour. Before induction begins, each woman will have a transperineal ultrasound scan of the pelvic floor at rest, on maximum contraction and on maximum Valsalva. The scan does not involve any vaginal probe, radiation or injection, and takes about 15 minutes. The times of each phase of labour, the way the baby is born and the condition of the perineum after birth will be recorded prospectively from the clinical record. The scan will be repeated before hospital discharge and about one month after birth, together with validated pelvic floor symptom questionnaires. The main question is whether the area of the levator hiatus measured on Valsalva before induction is related to the duration of the active, pushing phase of the second stage of labour. The study will also examine the duration of the first stage, the mode of delivery, and how the pelvic floor changes in the first month after an induced birth. Study procedures do not influence clinical care in any way: induction and labour are managed according to standard departmental protocols, and the research ultrasound results are not disclosed to the clinical team.

Participants needed: 140
Trial details
Age: 18+Biological sex: FemaleType: ObservationalSponsor: University of Roma La SapienzaUpdated: Sep 3, 2026Locations: 1
Eligibility criteria

Age 18 years or older [+5]

Multiple pregnancy or non-cephalic presentation [+7]

Status: Recruiting

Postpartum Effects of Mirror Therapy During Labor

Today, childbirth is considered one of the most physically and psychologically intense experiences in a woman's life. Labor is a critical period during which fear, anxiety, and stress related to childbirth may increase, potentially affecting both the course of labor and postpartum emotional well-being. Supportive approaches implemented during this period may contribute to a more positive perception of the childbirth experience and enhance postpartum well-being. Mirror therapy is a non-pharmacological approach that enables individuals to visually perceive their own bodies and the ongoing process, thereby strengthening self-perception and promoting positive body awareness. The use of mirror therapy during labor may increase women's active participation in the childbirth process and enhance their sense of control. It may also support emotional well-being and reduce negative emotional states during the postpartum period. Accordingly, this study aims to evaluate the effects of mirror therapy administered during labor on postpartum pain, mood, and emotional well-being. The findings are expected to contribute to strengthening midwifery support during childbirth, integrating non-pharmacological approaches into clinical practice, promoting their wider use, and protecting women's psychological well-being. Thus, the study is expected to provide scientific evidence that may inform midwifery education and practice as well as postpartum care policies.

Participants needed: 86
Trial details
Age: 18+Biological sex: FemaleType: InterventionalSponsor: NURTEN ÖZÇALKAPUpdated: Sep 1, 2026Locations: 1
Eligibility criteria

Women aged 18 years or older, [+4]

Having difficulty communicating, [+2]

Status: Recruiting

Impact of Prophylactic Ephedrine on Fetal Heart Tracing and Uterine Tetanic Contraction After CSE

Labor analgesia is an important component of the care of laboring patients. A known side effect of combined spinal and epidural anesthesia (a type of labor analgesia) is an increased incidence of category II fetal heart rate tracing (defined below) and low blood pressure. The study team aims to study if a prophylactic dose of ephedrine will decrease the occurrence of this type of tracing after combined spinal epidural (CSE) anesthesia placement. Ephedrine is not currently routinely used as prevention for category II tracings or low blood pressure. The use of Ephedrine in this study is investigational (this is the first time that the drug has been studied for its effect on these conditions). Fetal heart rate (FHR) tracings are classified into three categories. In clinical practice, FHR tracing categories are used as a guide to obstetric management and suggest the following approach: * Category I tracing is "reactive" and reassuring → may continue labor * Category II tracing is neither category I nor category III. For obvious reasons, category II is the broadest and largest category, consisting of various FHR tracing patterns that do not fit into either category I or category III. * Category III tracing is non-reassuring → expedited vaginal or cesarean delivery recommended. A Category II tracing is not diagnostic. Most pregnancies have at least one Category II tracing. There is not always an identifiable reason for a Category II tracing. Ephedrine is a medication that causes an increase in heart rate and blood pressure while also causing some degree of relaxation of the uterus therefore improving uterine blood flow. It has been used in the obstetric population for over 50 years without issues. The dose that the research team will administer, 7.5 mg, is below the dose the research team will often administer to treat hypotension (low blood pressure).

Participants needed: 100
Trial details
Phase: Phase 4Age: 18-55Biological sex: FemaleType: InterventionalSponsor: Icahn School of Medicine at Mount SinaiUpdated: May 6, 2026Locations: 1
Eligibility criteria

Women aged 18-55 years [+3]

Refusal of neuraxial anesthesia [+3]

Status: Not yet recruiting

The Effect of Chocolate Consumption During Labor on Second Stage Duration

Childbirth is an energy-intensive physiological process, requiring sustained effort comparable in intensity to moderate physical activity. Studies suggest that providing an available energy source during labor, such as dextrose infusion or natural carbohydrate-rich foods such as dates, may shorten the duration of labor and improve cervical dilation without adversely affecting obstetric outcomes. The primary objective of the study is to examine whether giving chocolate during labor affects the duration of the second stage of labor, compared to a control group that will not receive a nutritional intervention. The study is a prospective, randomized, controlled trial that will be conducted in the delivery room of Hillel Yaffe Medical Center. Healthy pregnant women with a singleton pregnancy at ≥37 weeks gestational age, in spontaneous or induced labor, without diabetes (pre/gestational), will be recruited to participate. Participants in the intervention group will receive one serving of 50 grams of milk chocolate (cocoa content 25-30%, without filling or additives) at a cervical dilation of 6 cm or more (and not yet fully dilated). The mother will be asked to consume the serving gradually over 30 minutes. Milk chocolate was chosen because it is better tolerated compared to dark chocolate, has a more gentle profile of active ingredients (which can increase nausea and heartburn) and provides a source of available carbohydrates. The study will be conducted in accordance with the guidelines of the Ministry of Health's procedure for medical experiments on humans, and will be conducted after approval by the Institutional Helsinki Committee.

Participants needed: 180
Trial details
Age: 18-50Biological sex: FemaleType: InterventionalSponsor: Hillel Yaffe Medical CenterUpdated: Feb 4, 2026
Eligibility criteria

Gestational age ≥37 weeks [+4]

Multiple pregnancies [+7]

Status: Not yet recruiting

The Effect of Pregnant-controlled Sacral Massage on Mothers' Labor Pain, Perception, Process and Midwives' Satisfaction

Our study aims to determine the effect of pregnant-controlled automatic sacral massage on mothers' labor pain, perception, process and midwives' satisfaction. The research was planned as a randomized controlled experimental study. A total of 112 women, 56 pregnant women in the experimental and control groups, will be included in the study. In this project, an automatic massage device will be used during the active phase (when the cervical opening is between 5-6 cm and 10 cm) and a massage device in line with the pregnancy-controlled sacral massage application protocol. Pregnant women are followed throughout the active phase of labor and indicators reflecting labor pain, progress of labor, and the health status of the mother and the baby are used with the "Individual Identification Form", "Visual Comparison Scale", "Labor Monitoring Form", "Mother's Birth Perception Scale (ADAS)". The satisfaction of midwives will be evaluated with the "Evaluation of Satisfaction Status of Midwives Form".

Participants needed: 112
Trial details
Age: 18-45Biological sex: FemaleType: InterventionalSponsor: Osmaniye Korkut Ata UniversityUpdated: Jul 15, 2024
Eligibility criteria

Participating in the study voluntarily [+5]

having pregnancy complications [+2]