Labor and Delivery

4

Review clinical trials related to Labor and Delivery. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

The Ophthalmic Artery Doppler Evaluation Prior to Labor Induction and Adverse Intrapartum Fetal Outcomes

The ophthalmic artery Doppler has been recently proposed as a potential "soft marker" for placental insufficiency in retrospective and observational studies, with similar clinical significance with respect to Uterine Artery (UA) Doppler evaluation and it is currently being investigated as an adjunctive clinical instrument to predict pre-eclampsia (PE) occurrence. Placental insufficiency strictly correlates with intrapartum fetal adverse outcomes and a concomitant induction of labor, alone, may further increase the hypoxic stress on the fetus during labor. This can be reflected by cardiotocographic alterations during labor, ultimately leading to emergency cesarean deliveries or instrumental vaginal deliveries. Despite great advancements in understanding various maternal-fetal pathologies, the investigators are still not able to properly detect fetuses that are at higher risk for intrapartum compromise among those receiving an induction of labor. Therefore, the aim of this prospective study is to investigate any potential association between altered ophthalmic artery Doppler PSV ratio measured before labor induction in at-term, pregnant patients with intra-partum fetal compromise. Furthermore, the investigators aim to also measure an additional parameter that is the optic nerve sheath diameter (ONSD) - an indirect measure of intracranial pressure - before and after the second stage of labour, with the aim of studying its physiology during and after delivery.

Participants needed: 1,477
Trial details
Age: 18+Biological sex: FemaleType: InterventionalSponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCSUpdated: Sep 29, 2026
Eligibility criteria

Age ≥18 years [+2]

Age <18 years [+5]

Status: Not yet recruiting

Role of the WHO Labour Care Guide in Improving Maternal and Fetal Outcomes

The goal of this randomized controlled trial is to compare the effectiveness of WHO labour care guide (LCG) with the WHO modified partogragh in improving the maternal and fetal outcomes among primigravida and multigravida in active labour .the study evaluates whether use of the Labour care guide leads to improved labour monitoring ,timely clinical decision making and better maternal and neonatal outcomes .this study will answer either of the two questions that is * There is no difference in maternal and fetal outcomes between women monitored with Wo labour care guide (LCG) and those monitored with the Modified Partogragh * There is a difference in maternal and fetal outcomes between women monitored with the WHO Labour care guide (LCG) and those monitored the modified Partogragh .

Participants needed: 114
Trial details
Age: 20-40Biological sex: FemaleType: InterventionalSponsor: Khyber Teaching HospitalUpdated: Mar 3, 2026Locations: 1
Eligibility criteria

patient aged 20 to 40 years . [+4]

patients with breech presenation [+3]

Status: Recruiting

Ropivacaine and Fentanyl for Labor Epidural Initiation

This study is being done to determine the most effective dose of medicine to use to initially provide effective pain relief within the first 30 minutes of receiving an epidural for pain labor during labor. The study team will also study any side effects related to the epidural medication and patients' satisfaction with the quality of pain relief after receiving the epidural.

Participants needed: 50
Trial details
Phase: Phase 3Age: 18+Biological sex: FemaleType: InterventionalSponsor: University of California, San FranciscoUpdated: Jan 27, 2026Locations: 1
Eligibility criteria

Patients with singleton vertex pregnancies in active labor (latent or spontaneou... [+3]

Significant obstetric disease (e.g., pre-eclampsia, major cardiac disease) [+7]

Status: Not yet recruiting

Visual Biofeedback Through Transperineal Ultrasound During the Expulsive Phase of Labour to Improve Maternal Childbirth Satisfaction

Childbirth is generally regarded as a positive life-changing experience. Up to 44% of women may however experience this as a traumatic event, with 3% suffering from post-traumatic stress disorder after childbirth. The aetiology of a traumatic childbirth experience is a complex interplay between pre-birth, intra-partum and postnatal factors. Feelings of loss of control, lack of interaction with the obstetric caregiver and lack of emotional or practical support during labour are important contributing factors. This trial aims to investigate the effect of providing Visual Biofeedback (VB) through Trans-Perineal Ultrasound (TPU) during the active 2nd stage of labour on maternal childbirth satisfaction. The hypothesis is that the intervention will improve patient-caregiver communication and enhance parturient women's sense of control and empowerment, ultimately improving the birth experience.

Participants needed: 488
Trial details
Biological sex: FemaleType: InterventionalSponsor: Universitaire Ziekenhuizen KU LeuvenUpdated: Feb 26, 2025Locations: 1
Eligibility criteria

Voluntary written informed consent of the participant. [+6]

Significant psychiatric comorbidity (psychiatric follow-up during pregnancy, or... [+6]