Health TrialsbyHealthPanel

Leptomeningeal Disease (LMD)

2

Review clinical trials related to Leptomeningeal Disease (LMD). Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

A Study of SX-682 in Combination With Proton Craniospinal Irradiation (pCSI) in People With Leptomeningeal Disease

The researchers are doing this study to find out whether SX-682 in combination with proton craniospinal irradiation (pCSI) is a safe treatment approach for people with melanoma or non-small cell lung cancer (NSCLC) with leptomeningeal disease (LMD). The researchers will also look at whether the treatment combination is effective against participants' cancer.

Participants needed: 40
Trial details
Phase: Phase 1Age: 18+Biological sex: AllType: InterventionalSponsor: Memorial Sloan Kettering Cancer CenterUpdated: Sep 11, 2026Locations: 7
Eligibility criteria

Age ≥ 18 [+33]

Patient who is unable to undergo MRI brain and spine with gadolinium contrast [+2]

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Status: Recruiting

Exploring the Feasibility of Cerebrospinal Fluid (CSF) and Blood Plasma Liquid Biopsy in Patients With Metastatic Solid Tumours and Primary Central Nervous System (CNS) Tumours: A Pilot Study

This is a prospective, single-centre feasibility study of CSF ctDNA conducted at the Sunnybrook Odette Cancer Centre (SOCC), Toronto, Canada, including multiple solid tumor, stratified into cohorts according to CNS disease involvement, including leptomeningeal disease (Cohort A), parenchymal brain metastases (Cohort B), and no evidence of CNS metastases (Cohort C).

Participants needed: 60
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Sunnybrook Health Sciences CentreUpdated: Jul 31, 2026Locations: 1
Eligibility criteria

Patients in Cohort A will have previously untreated or progressing leptomeningea... [+7]

Inability to understand or unwillingness to provide written informed consent (la... [+1]

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