Low-Risk Myelodysplastic Syndrome (LR-MDS)

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Review clinical trials related to Low-Risk Myelodysplastic Syndrome (LR-MDS). Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

Safety and Tolerability of REGN17235 in Adult Participants With Clonal Cytopenia of Undetermined Significance and Low-Risk Myelodysplastic Syndrome With SF3B1 Mutation

This study will test a study drug called REGN17235 (the "study drug") to see if it can help treat Clonal Cytopenia of Undetermined Significance (CCUS) and Low-Risk Myelodysplastic Syndrome (LR-MDS) with a specific genetic mutation (SF3B1 Mutation). The study is looking at: * What side effects the study drug might cause * How well the study drug works * How much of the study drug is in the blood at different times * If the body makes antibodies (proteins that attach to substances your body does not recognize) against the study drug; this may cause the study drug to not work as well. * What is the best dose of the study drug to treat CCUS and LR-MDS

Participants needed: 52
Trial details
Phase: Phase 1Age: 18+Biological sex: AllType: InterventionalSponsor: Regeneron PharmaceuticalsUpdated: Aug 7, 2026
Eligibility criteria

Presence of SF3B1 mutation in the bone marrow or peripheral blood AND diagnosis... [+2]

Clinically significant anemia due to non-MDS or non-CCUS etiologies (eg, iron de... [+4]