Lower Extremity Lymphedema

3

Review clinical trials related to Lower Extremity Lymphedema. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Evaluate Advanced Pneumatic Compression Device With Revised Compression Programming for Lymphedema Treatment

The goal of this pilot study is to learn if a revised method of compression improves lymphatic function compared to the current method of compression. The main questions: • Does the revised method of compression improve lymph movement and lymphatic propulsion?

Participants needed: 5
Trial details
Phase: Early Phase 1Age: 18+Biological sex: AllType: InterventionalSponsor: Tactile MedicalUpdated: Aug 11, 2026Locations: 1
Eligibility criteria

18 years of age or older [+4]

Heart failure (acute pulmonary edema, decompensated acute heart failure) [+10]

Status: Not yet recruiting

Aerobic Exercise Effects in Lower Extremity Lymphedema

Lower extremity lymphedema negatively affects patients' functional status, quality of life, and activities of daily living. Complete decongestive therapy (CDT) is considered the gold-standard conservative treatment for patients with lymphedema. CDT consists of manual lymph drainage (MLD), skin care, compression bandaging, and exercise. Several studies have demonstrated the effectiveness of CDT in patients with lower extremity lymphedema. However, the results of studies investigating the effectiveness of different types of exercise are inconsistent. Moreover, most of these studies have been conducted in patients with upper extremity lymphedema, and the outcome measures have generally been limited to limb circumference measurements and quality of life assessments. To the best of our knowledge, no previous study has comprehensively evaluated the effects of aerobic exercise on both ultrasonographic parameters (quantitative data) and functional outcomes in patients with lower extremity lymphedema, as planned in the present study. Therefore, this study was designed to contribute to the existing literature by investigating these effects.

Participants needed: 50
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Bursa Yuksek Ihtisas Training and Research HospitalUpdated: Jul 24, 2026
Eligibility criteria

Diagnosis of lower extremity lymphedema (unilateral or bilateral) [+3]

Cognitive impairment [+10]

Status: Recruiting

Respiratory and Relaxation Training in Lower Extremity Lymphedema

This randomized controlled trial aims to investigate the effectiveness of respiratory and relaxation training added to standard complex decongestive therapy (CDT) on muscle oxygenation, functional capacity, and limb volume in patients with lower extremity lymphedema. Participants will be randomly assigned to receive either standard CDT alone or CDT combined with respiratory and relaxation exercises. Outcomes will be assessed before treatment, immediately after treatment, and two months after completion.

Participants needed: 60
Trial details
Age: 18-65Biological sex: FemaleType: InterventionalSponsor: Toros UniversityUpdated: Jul 13, 2026Locations: 1
Eligibility criteria

Female patients aged 18 years or older. [+4]

Acute cellulitis or other active infection within the previous 2-4 weeks. [+5]