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Moderately to Severely Active Ulcerative Colitis

2

Review clinical trials related to Moderately to Severely Active Ulcerative Colitis. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

A Study to Evaluate the Pharmacokinetics, Safety and Efficacy of Afimkibart (RO7790121) in Children With Moderately to Severely Active Ulcerative Colitis

This Phase III, randomized, double-blind, multicenter, induction and maintenance study will evaluate the safety and efficacy of Afimkibart (RO7790121) in pediatric participants with moderate to severe active ulcerative colitis (UC).

Participants needed: 100
Trial details
Phase: Phase 3Age: 2-17Biological sex: AllType: InterventionalSponsor: Hoffmann-La RocheUpdated: Oct 6, 2026Locations: 26
Eligibility criteria

Bodyweight >= 10 kilogram (kg) [+3]

Monogenic disorder pertaining to infant onset inflammatory bowel disease (IBD) [+5]

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Status: Not yet recruiting

A Study to Assess the Efficacy and Safety of Afimkibart for Induction Therapy in Participants With Moderately to Severely Active Ulcerative Colitis

The purpose of this study is to assess the efficacy and safety of subcutaneous induction with afimkibart in participants with moderately to severely active ulcerative colitis (UC).

Participants needed: 350
Trial details
Phase: Phase 3Age: 16-80Biological sex: AllType: InterventionalSponsor: Hoffmann-La RocheUpdated: Sep 29, 2026
Eligibility criteria

Confirmed diagnosis of UC. [+5]

Currently known complications of UC (e.g. fulminant colitis, toxic megacolon). [+9]

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