Nasal Septum Deviation

4

Review clinical trials related to Nasal Septum Deviation. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

Clinicoradiological Correlation Between Long Standing Untreated Adenoids and Nasal Septum Deviation in Adolescents

The adenoids, also known as pharyngeal tonsils, are the peripheral immune organs of the human body and are located at the junction of the nasopharyngeal parietal and posterior walls. The adenoids represent the first defense portal of the respiratory tract and the earliest site of exposure to various antigens by inhalation or ingestion This can result in adenoid hypertrophy (AH) due to repeated stimulation by various antigens and their own inflammation (1) . AH is the chronic enlargement of the adenoids usually accompanied by recurrent infections. Adenoids which are enlarged are capable of becoming practically the ping pong ball sized and wholly obstruct airflow in the course of nasal cavities (2) . AH is commonly encountered in children and is a well-recognized cause of nasal obstruction. Typically, the tissue undergoes involution during adolescence, and its persistence into adulthood is considered unusual. However, AH in adolescents is thought to be a persistence of untreated AH of childhood (3) In such cases, persistent adenoid hypertrophy may continue to cause chronic nasal obstruction and prolonged mouth breathing. Mouth breathing alters the normal functional balance between the tongue, lips, and buccal muscles, which may contribute to narrowing of the maxillary arch and development of a high-arched palate during childhood growth. If adenoid hypertrophy and nasal obstruction remain untreated, these functional and structural changes may persist into adolescence (4) . As the hard palate forms the floor of the nasal cavity, a high-arched palate and associated maxillary changes may alter the shape and available space of the nasal cavity. Such anatomical changes may * may influence the configuration of the nasal septum, particularly during the growing years, 2 providing a possible structural link between long-standing adenoid hypertrophy and septal deviation (5) Despite the recognized effects of chronic adenoid obstruction on nasal breathing and craniofacial development, evidence specifically addressing whether long-standing untreated AH is associated with septal deviation remains limited. so, this study aims to investigate the clinicoradiological correlation between long-standing untreated AH and nasal septal deviation in adolescent

Participants needed: 50
Trial details
Age: 10-18Biological sex: AllType: ObservationalSponsor: Assiut UniversityUpdated: Sep 11, 2026
Eligibility criteria

Age 10 to18 years. Both sexes. Adolescents with long standing untreated adenoid...

Previous adenoidectomy or nasal surgery. History of significant nasal trauma or...

Status: Not yet recruiting

Effect of Controlled Hypotension on GFAP and Cognition in Rhinoplasty

This prospective observational study aims to evaluate the neurological safety of controlled hypotension (Mean Arterial Pressure 50-65 mmHg) during elective rhinoplasty. The investigators will assess whether this standard intraoperative hypotensive strategy causes cellular stress by measuring serum Glial Fibrillary Acidic Protein (GFAP) levels and early postoperative cognitive changes using the Montreal Cognitive Assessment (MoCA) test.

Participants needed: 40
Trial details
Age: 18-50Biological sex: AllType: ObservationalSponsor: Kahramanmaras Sutcu Imam UniversityUpdated: Jul 14, 2026
Eligibility criteria

Scheduled for elective rhinoplasty or septorhinoplasty under general anesthesia. [+2]

History of neurological (e.g., cerebrovascular event, epilepsy) or psychiatric d... [+4]

Status: Not yet recruiting

Disarticulation Septoplasty Versus Classical Way

The objective of this study is to determine which of the two techniques (disarticulation septoplasty versus open surgery) offers the best functional results for correcting symptomatic deviations of the nasal septum. More specifically it's about: * Compare the improvement in respiratory symptoms between the two techniques * Analyze and compare complication rates between the two techniques * Evaluate patient satisfaction with aesthetic results (including columella deviation)

Participants needed: 40
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Hôpital NOVOUpdated: Feb 19, 2026Locations: 1
Eligibility criteria

Patient aged 18 and over [+2]

Patient with septal perforations [+5]

Status: Not yet recruiting

Outcomes of PRF on Septoplasty in Patient With Nasal Septal Deviation

The aim of this study is to assess the effectiveness of Platelet-Rich Fibrin (PRF) in improving postoperative healing, reducing complications, and enhancing functional outcomes in patients undergoing septoplasty

Participants needed: 100
Trial details
Age: Up to 65Biological sex: AllType: InterventionalSponsor: Kafrelsheikh UniversityUpdated: May 30, 2025
Eligibility criteria

Adults aged 18-65 years undergoing septoplasty. Presence of cartilage deviated n...

History of coagulopathy or anticoagulant therapy. Active infection or systemic d...