Status: Recruiting
Effect of GLP1 Receptor Agonist on Brain Insulin Responsiveness
The overarching goal of the current study is to investigate the effect of GLP-1 on brain insulin responsiveness in a randomized, single-blinded, within subject cross-over study design. To this end, investigators will compare the effect of the administration of semaglutide versus placebo, followed by an fMRI with administration of intranasal insulin or placebo.
Participants needed: 60
Trial details
Age: 18-70Biological sex: AllType: InterventionalSponsor: University Hospital TuebingenUpdated: Mar 30, 2025Locations: 1
Eligibility criteria
BMI between 18.5 and 24.9 kg/m2; and between 27.5 kg/m2 and 40 kg/m2 [+2]
Type 1 or type 2 diabetes, LADA, MODY, or cardiovascular diseases such as chroni... [+26]