Status: Not yet recruiting
Preoperative Optimization With Tirzepatide, Ketogenic Diet, or Standard Care Before One Anastomosis Gastric Bypass Surgery
This study compares three preoperative strategies before one anastomosis gastric bypass(OAGB) for severe obesity. Participants will be assigned to receive either tirzepatide medication for 60 days, a ketogenic diet for 4 weeks, or standard care before surgery. The main goal is to determine which approach leads to the best weight loss one year after surgery. The study will also evaluate safety, surgical outcomes, and improvement of obesity-related health conditions such as diabetes, high blood pressure, and sleep apnea.
Participants needed: 96
Trial details
Age: 18-65Biological sex: AllType: ObservationalSponsor: Mario Musella MDUpdated: Sep 10, 2026Locations: 1
Eligibility criteria
Age 18 to 65 years at enrollment [+6]
History of any prior bariatric procedure or major upper gastrointestinal surgery... [+8]