Overdose

5

Review clinical trials related to Overdose. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

Permanent Supportive Housing Overdose Prevention+ Study

This community-partnered study examines a technical assistance intervention designed to help permanent supportive housing agencies implement evidence-based practices to prevent tenant overdose and improve tenant health.

Participants needed: 2,940
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: NYU Langone HealthUpdated: May 6, 2026Locations: 1
Eligibility criteria

Serve at least 40 tenants in New York and/or New Jersey [+4]

See inclusion criteria.

Status: Not yet recruiting

The Community Paramedic Response and Overdose Outreach With Supportive Medical-Legal Services Study

The goal of this clinical trial is to develop and test the CROSSROADS intervention. CROSSROADS is designed for people who have recently survived an opioid and/or stimulant-related non-fatal overdose and had contact with staff from a Community Paramedic (CP) program. Participants will be randomly placed into one of two groups: 1\) Standard of care from the CP program, or 2) CROSSROADS, which includes CP care plus a Medical-Legal Partnership (MLP). The MLP helps people with legal problems that can affect their health-- like issues with housing or public benefits. Researchers will test if the CROSSROADS intervention reduces drug use and involvement with the criminal legal system. People in the study will be followed for one year and asked to complete surveys at the beginning, and again at 1 month, 6 months, and 12 months.

Participants needed: 400
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Duke UniversityUpdated: Apr 13, 2026Locations: 4
Eligibility criteria

18 years old or older; [+4]

Status: Not yet recruiting

Overdose Prevention Centers and Behavioral Health

The aims of this study are: (Aim 1) Identify sources of heterogeneous impacts of opioid prevention center (OPC) use on non-fatal and fatal overdose risk among individuals with histories of polysubstance use (PSU); (Aim 2) Estimate the impact of OPC use on treated psychiatric events among clients with histories of PSU, and; (Aim 3) Assess the barriers and facilitators of integrating mental health services into existing syringe service and OPC delivery models.

Participants needed: 500
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: NYU Langone HealthUpdated: Mar 2, 2026Locations: 1
Eligibility criteria

are 18 years of age or older; [+10]

Status: Recruiting

Emergency Medicine Peer Outreach Worker Engagement for Recovery

This is an observational, prospective case-control study evaluating the effects of an emergency department community health worker-peer recovery specialist program (PCHW), the Substance Misuse Assistance Response Team (SMART). Aims of this study are to 1) understand participant experiences working with a SMART PCHW and identify possible mechanisms for successful recovery linkage; 2) Evaluate SMART effectiveness on patient-centered outcomes, building recovery capital, and recovery linkage; 3) Evaluate SMART implementation and effectiveness on patient outcomes over time. Using a combination of surveys and data linkages to state administrative databases, study investigators will prospectively compare changes in addiction treatment engagement, recovery capital, health related social needs, acute care utilization, and death between people receiving a ED PCHW and those who do not. After consenting to study participation, participants will complete surveys at time of study enrollment and 3 and 6 months after their initial ED visit. Primary outcomes include engagement in addiction treatment, social services engagement, acute care utilization, and mortality will be assessed through linkages to state administrative databases.

Participants needed: 400
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: University of California, Los AngelesUpdated: Oct 6, 2025Locations: 1
Eligibility criteria

Adults 18 years old or older [+4]

Unable to provide informed consent [+1]

Status: Recruiting

Shelter HArm Reduction Evaluation

The proposed study will use mixed methods research to examine overdose and other health-related impacts of harm reduction initiatives in NYC homeless shelters.

Participants needed: 80
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: NYU Langone HealthUpdated: Sep 12, 2025Locations: 1
Eligibility criteria

Adult 18 year of age or older [+12]