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Persistent Pulmonary Hypertension of Newborn

3

Review clinical trials related to Persistent Pulmonary Hypertension of Newborn. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Effect of Melatonin on Pulmonary Hypertension in Full Term Neonates

The aim of the study 1. To evaluate safety and efficacy of melatonin as an adjuvant therapy to inhaled nitric oxide generated by NO generator in the treatment of pulmonary hypertension in full term neonates. 2. To assess the effect of inhaled nitric oxide and melatonin on cerebral perfusion.

Participants needed: 52
Trial details
Biological sex: AllType: InterventionalSponsor: Ain Shams UniversityUpdated: Sep 30, 2026Locations: 1
Eligibility criteria

Term neonates with gestational age ≥ 37 weeks. [+1]

Congenital methemoglobinemia. [+3]

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Status: Recruiting

Treprostinil in Newborns With Pulmonary Hypertension; a Non-Interventional Study to Collect Data on Drug Utilization, Safety, and Effectiveness

This observational study will seek to describe the uses and safety and efficacy outcomes of treprostinil in clinical practice in patients with persistent pulmonary hypertension (PPHN).

Participants needed: 60
Trial details
Age: Up to 44Biological sex: AllType: ObservationalSponsor: Ferrer Internacional S.A.Updated: Sep 3, 2025Locations: 4
Eligibility criteria

Newborn infants who received at least one dose of IV or SC treprostinil as per c... [+4]

None.

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Status: Recruiting

Nebulized Magnesium Sulfate and Sildenafil for Persistent Pulmonary Hypertension of Newborn

The aim of this study is to evaluate the effectiveness of nebulized magnesium sulfate combined with sildenafil citrate, compared with sildenafil citrate alone, in treating neonates with severe persistent pulmonary hypertension on mechanical ventilation.

Participants needed: 40
Trial details
Phase: Phase 1, Phase 2Age: 6-72Biological sex: AllType: InterventionalSponsor: Sohag UniversityUpdated: Nov 27, 2024Locations: 1
Eligibility criteria

Gestational age ≥ 36 weeks [+5]

Failure to obtain informed consent [+8]

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