PME

Alcohol increases the risk for at least seven cancers, yet recent estimates suggest only between one-third and one-half of US adults are aware of this risk. The current study aims to develop and test alcohol-cancer messages designed for a mass media public health campaign. The messages will be informed by theory-based constructs proximal to health behavior change (e.g., perceived likelihood/severity of harm, response efficacy). We will evaluate messages via an online, cross-sectional message testing randomized experiment. Participants will be US adults aged 21+ recruited from Qualtrics Panels.

The Registry and Natural History Study for Progressive Myoclonus Epilepsy Type 1 (EPM1) is focused on gathering longitudinal clinical data as well as biological samples (blood and/or urine) from male and female patients, of all ages, who have a molecular diagnosis of EPM1or CSTB-null-related disease. Currently, there are no therapies that halt disease progression in any CSTB-related diseases, highlighting the urgency for translational research into this condition. The primary objective of the registry is to determine the natural history and genotype-phenotype correlations of disease-causing variants in EPM1 and CSTB-null-related disease.