Posterior Capsule Opacification

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Review clinical trials related to Posterior Capsule Opacification. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Clinical Evaluation of Low Contrast Visual Performance and Low Light Phenomena in Patients With Various Intraocular Lens Implants

The goal of this clinical investigation is to evaluate visual acuity and contrast sensitivity in low lighting conditions using several different testing devices, and measure nighttime side effects of intraocular lens (IOL) implants after cataract surgery. Researchers will compare the results for three different types of IOLs to see how each lens contributes to overall visual function, patient experience and satisfaction. Participants will: * Complete two different questionnaires about their current vision * Undergo visual testing using several different devices

Participants needed: 120
Trial details
Age: 22+Biological sex: AllType: ObservationalSponsor: Dr. Daniel H. Chang, MDUpdated: Sep 25, 2026Locations: 1Duration: 1 Day
Eligibility criteria

Minimum 22 years of age [+4]

Any clinically significant pupil abnormalities (non-reactive, fixed pupils, or a... [+5]

Status: Not yet recruiting

IOL Position and Refractive Change After Nd:YAG Laser Posterior Capsulotomy

After cataract surgery, the thin natural membrane that holds the artificial lens in place can slowly turn cloudy. This is called posterior capsule opacification. It makes vision blurry and can cause glare. The standard treatment is a short, painless laser procedure called Nd:YAG capsulotomy, which opens a small clear window in the cloudy membrane. Opening this membrane changes the support structure around the artificial lens. Eye doctors do not agree on what happens next. Some studies found that the lens shifts slightly backward in the eye after the laser treatment, some found that it shifts forward, and some found no movement at all. It is also unclear whether such a small shift changes how well a person sees or the strength of their glasses. One reason for these mixed results may be that each study used a different imaging device, and these devices measure the depth of the front chamber of the eye in different ways. This study measures the position of the artificial lens in the same eye with three different imaging devices, before and after the laser treatment. The devices are called IOLMaster 700, CASIA2, and Pentacam AXL. All three take detailed pictures of the front of the eye without touching it. The study team wants to find out whether the artificial lens moves after the laser treatment, how much it moves, whether any movement changes vision or the glasses prescription, and whether the three devices give matching results. Who can take part People who had cataract surgery at least three months ago, who now have a cloudy membrane behind the artificial lens, and whose eye doctor has already decided that the laser treatment is needed. What taking part involves Taking part does not change the laser treatment in any way. The decision to perform the treatment, the technique, and the laser settings are made by the treating doctor for medical reasons and are not influenced by the study. The study only adds extra measurements before and after the treatment. There are three study visits: * Visit 1, on the day of the laser treatment and before the laser is used. The extra measurements take about 30 to 45 minutes. * Visit 2, about one week after the treatment. The extra measurements take about 15 to 20 minutes. * Visit 3, about one month after the treatment. The extra measurements take about 30 to 45 minutes. At each visit the study team checks how well you can see, measures the strength of glasses that gives you the sharpest vision, examines your eye with a slit lamp, measures the pressure inside your eye, and takes images with the imaging devices. All of these are standard eye examinations used in everyday clinical practice. Nothing is inserted into the eye, and there are no injections, no medicines, and no radiation. Drops to widen the pupil are not needed for the study. Taking part is voluntary. You can stop at any time, without giving a reason and without any disadvantage for your medical care. Your laser treatment and all routine follow-up visits go ahead either way. There is no payment for taking part, and taking part brings no direct medical benefit. However, the detailed examination may reveal something that would not be noticed during routine follow-up, such as raised eye pressure. If this happens, you will be told and any necessary care will be arranged as part of your normal treatment at no extra cost. Study data are stored under a study code instead of your name.

Participants needed: 80
Trial details
Age: 18-100Biological sex: AllType: ObservationalSponsor: Vienna Hospital AssociationUpdated: Sep 3, 2026Locations: 1
Eligibility criteria

Pseudophakic eye with visually significant posterior capsule opacification for w... [+5]

Complicated cataract surgery, including posterior capsule rupture, vitreous loss... [+8]

Status: Recruiting

IC-8 Apthera IOL New Enrollment Post Approval Study

The purpose of this study is to verify the post-market safety of the IC-8 Apthera IOL after the treatment of posterior capsular opacification (PCO), an expected complication related to IC-8 Apthera IOL implantation.

Participants needed: 435
Trial details
Age: 22+Biological sex: AllType: ObservationalSponsor: Bausch & Lomb IncorporatedUpdated: Jan 12, 2026Locations: 14
Eligibility criteria

22 years of age or older, any race and any gender; [+6]

Pharmacologically dilated pupil size less than 7.0 mm in the IC-8 Apthera IOL ey... [+11]