Recurrent Chronic Myeloid Leukemia, BCR-ABL1 Positive

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Review clinical trials related to Recurrent Chronic Myeloid Leukemia, BCR-ABL1 Positive. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

HA-1 T TCR T Cell Immunotherapy for the Treatment of Patients With Relapsed or Refractory Acute Leukemia After Donor Stem Cell Transplant

This phase I trial studies the side effects and best dose of CD4+ and CD8+ HA-1 T cell receptor (TCR) (HA-1 T TCR) T cells in treating patients with acute leukemia that persists, has come back (recurrent) or does not respond to treatment (refractory) following donor stem cell transplant. T cell receptor is a special protein on T cells that helps them recognize proteins on other cells including leukemia. HA-1 is a protein that is present on the surface of some peoples' blood cells, including leukemia. HA-1 T cell immunotherapy enables genes to be added to the donor cells to make them recognize HA-1 markers on leukemia cells.

Participants needed: 24
Trial details
Phase: Phase 1Age: Up to 80Biological sex: AllType: InterventionalSponsor: Fred Hutchinson Cancer CenterUpdated: May 18, 2026Locations: 1
Eligibility criteria

Subject age 0-80 years at the time of enrollment. [+19]

Medical or psychological conditions that would make the subject unsuitable candi... [+6]