Refractory Childhood Neuroblastoma

1

Review clinical trials related to Refractory Childhood Neuroblastoma. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

Testing the Addition of an Anti-Cancer Drug, Daraxonrasib, for Relapsed or Refractory Solid Tumors With RAS Mutations

This phase I/II trial tests the safety, side effects, best dose and how well giving daraxonrasib works for the treatment of pediatric patients with solid tumors with RAS mutations that has come back after a period of improvement (relapsed) or that has not responded to previous treatment (refractory). Daraxonrasib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving daraxonrasib may be safe, tolerable and/or effective in treating patients with relapsed or refractory solid tumors with RAS mutations.

Participants needed: 77
Trial details
Phase: Phase 1, Phase 2Age: 1-17Biological sex: AllType: InterventionalSponsor: Children's Oncology GroupUpdated: Sep 15, 2026
Eligibility criteria

PARTS A1 AND B: Patients must be ≥ 2 years and ≤ 17 years of age at the time of... [+40]

Pregnant or breast-feeding women will not be entered on this study because there... [+21]