Shivering

11

Review clinical trials related to Shivering. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Effect Of Acupressure On Hypothermıa And Shıverıng After Cesarean Sectıon

This research was planned to determine the effect of acupressure on hypothermia and shivering after cesarean section. H01: There is no difference in hypothermia findings between women who received acupressure and women in the control group. H02: There is no difference in shivering findings between women who received acupressure and women in the control group. Women who present to the hospital for cesarean delivery and who meet the inclusion criteria and volunteer to participate in the study will be informed, and their verbal and written consent will be obtained. Before the acupressure application, the women will be interviewed face-to-face, and a pregnancy information form will be recorded by the researcher. Subsequently, a vital signs monitoring form, a temperature comfort perception scale, and a shivering level assessment form will be completed. Acupressure group: Half an hour prior to cesarean delivery, pressure was applied to the Yong Quan point (Kd1), the Chongyang point (ST42) on both feet, and the Zu San Li point (ST36) located under the patella. The application involved applying pressure to both feet simultaneously, first to ST42 and Kd1, then to ST36, for 3 minutes each time using the index finger, followed by a 3-minute rest period. This was repeated three times. Control group: Women who underwent cesarean section received routine postpartum care procedures.

Participants needed: 57
Trial details
Age: 18-35Biological sex: FemaleType: InterventionalSponsor: Ondokuz Mayıs UniversityUpdated: Oct 7, 2026Locations: 1
Eligibility criteria

who underwent elective cesarean section, [+5]

Women diagnosed with high-risk pregnancies, [+7]

Status: Not yet recruiting

Optimizing the Paracetamol Dose for Prevention of Post-Spinal Shivering in Lower Limb Orthopedic Surgeries

Shivering is a common and distressing complication following spinal anesthesia, affecting up to 70% of patients. It significantly increases oxygen consumption, places stress on the cardiovascular system, and interferes with postoperative monitoring. While intravenous paracetamol has been shown to reduce post-spinal shivering without the sedation or respiratory side effects associated with other medications, existing trials have only investigated a standard 1-gram dose. This study aims to evaluate whether a higher dose of intravenous paracetamol (2 grams) provides superior prevention of post-spinal shivering compared to the standard 1-gram dose and an inactive placebo. Adult patients scheduled for elective lower-limb orthopedic surgery under spinal anesthesia will be randomly allocated to one of three study groups: * High-dose group: intravenous paracetamol 2 g * Standard-dose group: intravenous paracetamol 1 g * Control group: intravenous normal saline placebo Each infusion will be administered over 15 minutes immediately prior to spinal anesthesia. Participants will be observed intraoperatively and for at least 60 minutes in the post-anesthesia care unit (PACU) to measure the incidence and severity of shivering, core body temperature changes, the need for rescue medication, and any adverse events.

Participants needed: 150
Trial details
Phase: Phase 4Age: 18-65Biological sex: AllType: InterventionalSponsor: Assiut UniversityUpdated: Oct 2, 2026
Eligibility criteria

Age 18 to 65 years [+4]

Patient refusal or inability to provide informed consent [+11]

Status: Not yet recruiting

Effect of Preoperative Intranasal Dexmedetomidine on Incidence of Intraoperative Shivering in Patients Undergoing Cesarean Section Under Spinal Anesthesia

Shivering is a common and distressing complication occurring in 40% to 60% of women undergoing cesarean section under spinal anesthesia. Beyond causing significant maternal discomfort, shivering markedly increases oxygen consumption and metabolic demand, elevates cardiopulmonary workload, and interferes with clinical monitoring. While intravenous meperidine remains a widely used pharmacological agent for shivering prophylaxis, it carries dose-dependent adverse effects such as nausea, vomiting, sedation, and potential neonatal depression. Intranasal dexmedetomidine provides an alternative needle-free method of administration that rapidly absorbs through the nasal mucosa and reduces shivering without suppressing respiratory drive. The primary purpose of this randomized controlled trial is to evaluate the efficacy of preoperative intranasal dexmedetomidine in reducing the incidence of intraoperative shivering compared with intravenous meperidine and placebo in women undergoing elective cesarean section under spinal anesthesia. A total of 99 parturients will be randomly allocated to one of three parallel groups (33 patients per group) using a double-dummy design: * Group D: Receives intranasal dexmedetomidine (1 mcg/kg) 30 minutes before spinal anesthesia, plus an intravenous saline placebo at spinal induction. * Group M: Receives intranasal saline placebo 30 minutes before spinal anesthesia, plus intravenous meperidine (0.5 mg/kg) at spinal induction. * Group C: Receives intranasal saline placebo 30 minutes before spinal anesthesia, plus intravenous saline placebo at spinal induction. Participants will be monitored throughout the surgical procedure to determine the occurrence of shivering, maternal hemodynamic parameters (heart rate, blood pressure, oxygen saturation), sedation levels using the Richmond Agitation-Sedation Scale (RASS), need for rescue anti-shivering medication, side effects, and neonatal outcomes (Apgar scores and birth weight).

Participants needed: 99
Trial details
Phase: Phase 4Age: 18-40Biological sex: FemaleType: InterventionalSponsor: Assiut UniversityUpdated: Oct 2, 2026
Eligibility criteria

Female patients aged 18 to 40 years. [+3]

Refusal to participate. [+8]

Status: Not yet recruiting

Intravenous Paracetamol Versus Magnesium Sulfate for Control of Shivering Following Spinal Anesthesia in Cesarean Section

Spinal anesthesia is widely used for cesarean deliveries, but shivering is a frequent complication that occurs in 40% to 60% of patients. Post-spinal shivering can cause maternal discomfort, increase oxygen consumption and metabolic demands, and interfere with clinical monitoring. Both paracetamol and magnesium sulfate have thermoregulatory properties that may prevent or reduce shivering. The purpose of this clinical trial is to compare the efficacy and safety of intravenous paracetamol versus intravenous magnesium sulfate in preventing and reducing shivering following spinal anesthesia in women undergoing elective cesarean section. A total of 90 pregnant women scheduled for elective cesarean delivery will be randomly assigned to one of two groups: * Group P (Paracetamol Group): Participants receive intravenous paracetamol (15 mg/kg) infused over 15 minutes immediately following the subarachnoid block. * Group M (Magnesium Sulfate Group): Participants receive intravenous magnesium sulfate (30 mg/kg) administered immediately following the subarachnoid block. The primary outcome evaluated is the severity of post-spinal shivering assessed by shivering scores. Secondary outcomes include hemodynamic parameters (heart rate, blood pressure, oxygen saturation), postoperative pain, complications such as nausea and vomiting, and maternal satisfaction.

Participants needed: 90
Trial details
Phase: Phase 4Age: 20-40Biological sex: FemaleType: InterventionalSponsor: Assiut UniversityUpdated: Oct 2, 2026
Eligibility criteria

American Society of Anesthesiologists (ASA) physical status class I or II [+4]

Patient refusal [+6]

Status: Not yet recruiting

Efficacy of Intravenous Midazolam-Ketamine Combination Versus Placebo for Prevention of Post-Spinal Shivering in Elective Cesarean Section

Spinal anesthesia is the preferred anesthetic method for elective cesarean deliveries, but it frequently causes post-spinal shivering. Shivering causes marked maternal discomfort, interferes with clinical monitoring, and increases oxygen consumption and metabolic workload. This study aims to assess whether a prophylactic intravenous combination of low-dose midazolam and low-dose ketamine reduces the occurrence and severity of shivering compared with a placebo in women undergoing elective cesarean delivery under spinal anesthesia. A total of 120 parturients will be randomly assigned into two equal groups: * Combination Group: Receives intravenous midazolam (0.0375 mg/kg) combined with ketamine (0.25 mg/kg) diluted in 20 mL of 0.9% normal saline. * Control Group: Receives 20 mL of 0.9% normal saline intravenously as a placebo. In both groups, the intravenous infusion is administered over 10 minutes immediately following delivery of the infant and clamping of the umbilical cord, ensuring no transplacental transfer of the study medications to the newborn. The primary objective is to evaluate the proportion of patients who develop shivering during the first 60 minutes after arrival in the post-anesthesia care unit (PACU). Secondary objectives include shivering severity, the requirement for rescue anti-shivering medication, intraoperative and postoperative sedation levels, hemodynamic stability, body temperature course, potential medication side effects, and maternal satisfaction.

Participants needed: 120
Trial details
Phase: Phase 4Age: 18-40Biological sex: FemaleType: InterventionalSponsor: Assiut UniversityUpdated: Oct 2, 2026
Eligibility criteria

Pregnant women aged 18 to 40 years old. [+4]

Patient refusal. [+8]

Status: Recruiting

Ondansetron Lozenge Versus Intravenous for Prevention of Shivering in Cesarean Section

This study aims to compare the effect of ondansetron lozenge and intravenous for prevention of shivering in cesarean section (CS).

Participants needed: 90
Trial details
Age: 18-40Biological sex: FemaleType: InterventionalSponsor: Tanta UniversityUpdated: Jun 23, 2026Locations: 1
Eligibility criteria

Age from 18 to 40 years. [+2]

Parturient women with any contraindication or hypersensitivity to the study drug... [+8]

Status: Recruiting

Comparative Study Between the Efficacy of Intravenous Hydrocortisone and Intravenous Dexmedetomidine for Prevention of Postoperative Shivering After General Anaesthesia for Abdominal Surgeries

The aim and purpose of this study is to compare the efficacy of intravenous hydrocortisone and intravenous dexmedetomidine for prevention and treatment of postoperative shivering after general anesthesia for abdominal surgeries.

Participants needed: 70
Trial details
Phase: Phase 4Age: 18-65Biological sex: AllType: InterventionalSponsor: Ain Shams UniversityUpdated: Sep 4, 2025Locations: 1
Eligibility criteria

Patients with known neurologic and psychiatric illness. [+5]

Status: Not yet recruiting

The Effect of Warmed Socks Developed as Wearable Technology on Hypothermia, Thermal Comfort Perception and Shivering

In this study, it is aimed to reveal the effect of the use of heated socks to be developed as wearable technology by providing temperature control on body temperature, comfort perception level and shivering development in healthy volunteers and this purpose constitutes the unique value of the project. The research was planned as a prospective, two-arm (1:1), randomized controlled, double-blind study. The population of the study will consist of 4th year nursing students consisting of an average of 250 people who will enroll in the fall semester of the 2024-2025 academic year. As a result of the power analysis performed in the G\*Power program, the sample will consist of 70 healthy volunteers, at least 35 in each group. In the study, data will be collected with the "Descriptive Characteristics Form" and "Hypothermia Monitoring Form (Shivering Level Diagnosis Form and Temperature Comfort Perception Scale)" which includes the descriptive information of healthy volunteers. Healthy volunteers will fill out the "Introductory Characteristics Form" and "Hypothermia Monitoring Form" before being taken to the Faculty of Nursing Skills Laboratory for the application. Before the volunteers are taken to the single rooms in the laboratory, the environment will be cooled for 30 minutes with the air conditioner in the room so that the temperature is 21oC. The study group will wear socks developed with wearable technology and the control group will wear socks with the same appearance. The healthy volunteer will be asked to lie motionless on the bed for 60 minutes in a single room. Body temperature (with Braun tympanic thermometer), shivering level and temperature comfort perception will be recorded on the "Hypothermia Monitoring Form" when all healthy volunteers are taken to the Skills Laboratory, at 15 minutes, 30 minutes and 60 minutes, and when they leave the laboratory. The research data will be analyzed in a computer environment. Descriptive variables of healthy volunteers included in the study will be expressed as mean±standard deviation and median (maximum minimum), percentage and frequency. Changes in body temperature measurements obtained after wearing socks to be developed with wearable technology, repeated measurements, analysis of variance (Repeated ANOVA) if parametric, Friedman test if non-parametric, and post-hoc test will be used in intra-group multiple comparison analysis as further analy

Participants needed: 70
Trial details
Biological sex: AllType: InterventionalSponsor: Tarsus UniversityUpdated: Sep 9, 2025
Eligibility criteria

-Written and verbal permission to participate in the study was obtained, [+8]

Written and verbal permission to participate in the research could not be obtain... [+8]

Status: Recruiting

Effect of Preemptive Education on the Incidence of Maternal Intraoperative Shivering in Elective Cesarean Delivery

The goal of this study is to learn about the effect of preemptive education on reducing intraoperative maternal shivering in elective cesarean delivery. The main question it aims to answer is: Does preemptive education by anesthesiologists reduce intraoperative maternal shivering in elective cesarean delivery?

Participants needed: 130
Trial details
Age: 19+Biological sex: FemaleType: InterventionalSponsor: Seoul National University HospitalUpdated: May 15, 2025Locations: 1
Eligibility criteria

Age 19 years or older [+2]

Emergency surgery [+4]

Status: Recruiting

Safe Brain Initiative, Operationalizing Precision Anaesthesia

Perioperatively, patients experience an unnecessarily high level of side effects associated with their treatment. These side effects include nausea, severe pain, anxiety, and stress. Moreover, many patients develop postoperative delirium (POD) and neurocognitive dysfunctions, often resulting in long-term cognitive impairment, decreased quality of life, and increased mortality. However, physicians, nurses and their institutions do not receive structured feedback regarding these aspects of each patient's well-being. They may therefore be unable to engage in the essential cause-and-effect learning necessary to evaluate and consecutively reduce such side effects. Effective guidelines conform prevention is the proven key to shielding our patients from adverse Outcomes. The Safe Brain Initiative's high-quality routine data-for-action is a sword and accelerator for moving towards patient-centred, precision care. Thus, establishing a foundation for value-based and patient-centred healthcare development. However, a turnkey real-world solution is challenging to develop and implement and requires substantial resources. As a result, such solutions are usually beyond the scope of a single institution. The SBI platform provides high-quality, real-world data to bridge this gap. It allows monitoring and in-depth analysis of cause and effect in the day-to-day routine of individuals, departments, and institutions. The SBI's approach is continuously improved and updated. An organization called the SBI Global Society oversees the quality and precision of science through experts in the field. At SBI Hospitals and Flagship centres, Masterclasses are conducted and can be attended alongside clinical immersions. SBI Solutions manages, develops, and provides technical and service support for the Safe Brain Initiative. Its service guarantees the professional and GDPR conform management of data handling and storage as well as the user-friendly functionality of the SBI-Dashboard solutions.

Participants needed: 15,000
Trial details
Age: 18-100Biological sex: AllType: ObservationalSponsor: University of Southern DenmarkUpdated: Jun 7, 2024Locations: 1Duration: 5 Years
Eligibility criteria

Not listed