Social Isolation in Older Adults

8

Review clinical trials related to Social Isolation in Older Adults. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

Improving Diet Quality of Community-Dwelling Seniors Using a Community-Based Participatory Approach

This study implements a community co-designed educational intervention program to improve diet quality of community-dwelling seniors.

Participants needed: 50
Trial details
Age: 60+Biological sex: AllType: InterventionalSponsor: Geriatric Education and Research InstituteUpdated: Oct 7, 2026Locations: 1
Eligibility criteria

aged 60 years and above [+5]

living with helpers [+12]

Status: Recruiting

Social Connection Collective for Older Adults in Subsidized Housing

This study will evaluate a resident-led program designed to promote social connection among older adults living in subsidized housing communities in Baltimore. A small group of residents, called Resident Champions, will receive training and support from the research team to form a Social Connection Collective and develop activities that encourage residents to connect with one another and build peer support networks. The study will assess whether the program is feasible and acceptable to residents and will explore whether participation is associated with changes in social isolation, social connectedness, and sense of belonging. Resident Champions will participate in approximately six group sessions over about six months, help organize community activities, and complete surveys and interviews before and after the intervention. Other residents in the housing communities may complete surveys about social connections and experiences.

Participants needed: 300
Trial details
Age: 62+Biological sex: AllType: InterventionalSponsor: Johns Hopkins UniversityUpdated: Oct 7, 2026Locations: 1
Eligibility criteria

Adults 62 years of age and older [+7]

Status: Not yet recruiting

A Pilot Study to Explore the Feasibility of Navigator and Coach Support for Community Participation by Older People

Frailty is a multidimensional syndrome in which a person accumulates age-related deficits across life domains, increasingly including social components such as social isolation. An estimated 12% of the Swiss population aged 65+ is frail and a further 46% pre-frail; without prevention, about two thirds of pre-frail persons will become frail, with major consequences for disability, hospitalisation, mortality, quality of life and health costs. Meta-analyses identify physical activity as the most promising prevention strategy, yet structured mechanisms connecting older adults with existing community activities remain underdeveloped and fragmented. To close this implementation gap, the ENGAGE implementation project co-designed a community participation support pathway with local stakeholders: older adults with low physical and/or social activity are systematically identified during routine contacts, a values-based conversation clarifies what matters to the person, the person is matched and referred to existing community activities, and a navigator (a social work professional acting as link worker) provides behavioural, practical and emotional support for initial and continued participation. Because there are uncertainties in the delivery of the study and intervention, a pilot study with a pragmatic randomised trial design is implemented.

Participants needed: 45
Trial details
Age: 65+Biological sex: AllType: InterventionalSponsor: Bastiaan Van GrootvenUpdated: Sep 23, 2026Locations: 1
Eligibility criteria

Age ≥65 years [+4]

Residing in residential long-term care [+3]

Status: Not yet recruiting

A Mechanism Randomised Controlled Trial of a Three-Agent LLM-Augmented mHealth Intervention for Late-Life Loneliness in Older Adults

This study examines how a smartphone conversational application affects feelings of loneliness in Cantonese-speaking older adults living in Hong Kong. Seventy-two adults aged 60 or above who report at least moderate loneliness will be randomly assigned to one of two versions of the same application. Both versions look and work the same way, offer the same three conversational companions, and provide the same set of in-app tools. The two versions differ only in how the companions' replies are produced: in one version replies are generated by a large language model, and in the other they are assembled from pre-written templates selected by keyword and conversation state. Participants use the application for four weeks and are then followed for a further four weeks with continued access. The main question is whether any difference between the two versions in emotional loneliness operates through how understood, validated and cared for participants feel during individual conversations. Participants are not told which version they are using, and the researcher who carries out the assessments is also unaware of the assignment.

Participants needed: 72
Trial details
Age: 60+Biological sex: AllType: InterventionalSponsor: The University of Hong KongUpdated: Sep 16, 2026
Eligibility criteria

Aged 60 years or above [+6]

Acute suicidality, defined as a PHQ-9 item 9 score above 1 with reported active... [+5]

Status: Recruiting

The ALIVE-Project: Activity, Life Satisfaction, Inclusion, Vitality, Elderly Women

Many older women live alone and may experience loneliness, reduced social participation, and declining physical health. Regular physical activity can improve health and independence, but it is not known whether exercising in a supervised group setting provides additional social and psychological benefits compared with exercising independently. The ALIVE study is a 16-week randomized controlled trial that will investigate the effects of fitness club participation on loneliness, social connectedness, quality of life, mental health, physical activity, and physical fitness in women aged 75 years and older who live alone and are insufficiently physically active. Participants will be randomly assigned to one of three groups: (1) supervised group exercise at a fitness club combined with opportunities for social interaction, (2) fitness club membership with independent exercise, or (3) a control group continuing their usual daily activities. A total of 213 women will be recruited from Oslo, Norway. Outcomes will be assessed before and after the intervention using questionnaires, physical performance tests, body composition measurements, cardiovascular risk assessments, and device-based measurement of physical activity. In addition, qualitative interviews will be conducted to explore participants' experiences, barriers, facilitators, and perceptions of social connection and belonging. The study aims to determine whether supervised group exercise in fitness clubs can reduce loneliness and improve health and well-being among older women, while generating knowledge about practical community-based strategies to support healthy and socially connected ageing.

Participants needed: 213
Trial details
Age: 75-100Biological sex: FemaleType: InterventionalSponsor: Norwegian School of Sport SciencesUpdated: Aug 27, 2026Locations: 1
Eligibility criteria

Women aged ≥75 years [+3]

Dementia or other cognitive impairment [+1]

Status: Recruiting

Tech-based Respite Care for Caregivers and Homebound Older Adults

The goal of this study is to examine the effectiveness of VR-based respite in improving cognitive function, mental health, and quality of life in caregivers and homebound older adults compared to a control group using videos and a usual care group. Participants are randomly assigned to one of three groups: VR intervention, video control, or usual care. The VR group receives immersive VR sessions using the SilVR Adventures platform. The video group receives non-immersive video sessions with similar content. The usual care group receives no additional intervention. Assessments are conducted at baseline, immediate post-intervention, and 3 months post-intervention to measure changes in depression, anxiety, loneliness, quality of life, and other outcomes. The intervention dosage will be 4 weeks (1 sessions/week; 30 min/session). Secondarily, the study explores differences in effectiveness between caregivers and homebound older adults, and potential moderators or mediators such as baseline health status, technological literacy, and social support.

Participants needed: 180
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Hong Kong UniversityUpdated: Jul 22, 2026Locations: 1
Eligibility criteria

Aged 18 or above [+5]

History of severe psychiatric disorders (e.g., schizophrenia, bipolar) [+11]

Status: Recruiting

Increasing Physical Activity Through Social Support and Stress Resilience

The goal of this clinical trial is to learn the effects of technology enhancements when combined with basic education, goal-setting, and self-monitoring to increase physical activity among older adults living alone, experiencing subjective cognitive decline, and currently engaging minimal physical activity (60 minutes or less of moderate to vigorous physical activity). Further, we will examine key psychosocial mechanisms believed to contribute to successful promotion of physical activity, which include social support and stress resilience. The primary questions are to determine whether * the tech-enhanced condition lead to greater physical activity over time? * the tech-enhanced condition lead to social support and stress resilience over time? * social support and stress resilience mediate the relationship between the study condition and physical activity? All participants will engage in self-monitoring of physical activity, will receive weekly text reminders of their physical activity goals for the week, and will receive basic education about the importance of physical activity, social support, and stress resilience for cognitive, physical, and psychological health. Participants in the tech-enhanced condition will also receive access to a study-specific website and virtual coaching to reinforce the information presented. Researchers will then compare the tech-enhanced condition to the basic education condition to determine the benefits of technology to deliver the intervention materials in order to increase physical activity, social support, and stress resilience. Participants will: * Use a Garmin wearable device to monitor their physical activity * Be randomly assigned to a basic education condition or tech-enhanced condition * Set achievable goals for weekly physical activity, with incremental increases to achieve 7000 average daily steps by the end of the study * Respond to surveys to monitor their social support, stress resilience, quality of life, and depression. The sample has several risk factors for Alzheimer's disease and related dementias: low physical activity, social isolation risk via living alone, and subjective cognitive impairment. Therefore, a long-term goal includes the determination of the intervention's effectiveness at increasing physical activity, social support, and stress resilience to reduce risk for developing dementia.

Participants needed: 86
Trial details
Age: 60+Biological sex: AllType: InterventionalSponsor: Arizona State UniversityUpdated: Jun 29, 2026Locations: 1
Eligibility criteria

Aged 60 years or older [+5]

Endorsing an item on the Physical Activity Readiness Questionnaire (PAR-Q), unle... [+9]

Status: Recruiting

CAPABLE Care + Connect

In this evaluation scale-up research project, the investigators seek to test an implementation of CAPABLE on the infrastructure of home-based primary care for individuals who may experience social isolation and/or loneliness. These two home-based care programs may improve each other and provide opportunity to further improve quality of life for people living with disabilities and the caregivers. The purpose of this mixed methods study is to adapt and test CAPABLE, an existing evidence-based program, to a new target population with the scalable infrastructure of home-based primary care.

Participants needed: 450
Trial details
Age: 50+Biological sex: AllType: InterventionalSponsor: Johns Hopkins UniversityUpdated: Jun 2, 2026Locations: 1
Eligibility criteria

Any patient currently in JHOME [+12]

Terminally ill [+2]