Substance Use Disorders (SUDs)

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Review clinical trials related to Substance Use Disorders (SUDs). Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

Enhancing Delivery of Parenting Support Within a Peer Recovery Support Service Model

The goal of this clinical trial is to evaluate the effectiveness and implementation of Relational Health Enhanced Parenting Support (RHEP), an implementation strategy designed to improve delivery of evidence-based parenting support within family-focused peer recovery support services (PRSS), for parents with substance use disorders (SUDs) receiving services through the FIRST Steps Together (FST) home visiting program. The main questions it aims to answer are: 1. Does FST plus RHEP improve parenting-related outcomes, substance use disorder treatment retention, and reduction in substance use compared with FST alone? 2. How do implementation processes vary across sites, and what role do peer recovery support specialists play in implementation and effectiveness outcomes? Researchers will compare FST alone to FST plus RHEP to determine whether RHEP enhances parenting support delivery and improves parent and recovery outcomes. Participants will: 1. Receive family-focused peer recovery support services through the FIRST Steps Together (FST) program; 2. Complete surveys and assessments related to parenting, recovery, and substance use over time; 3. Participate in follow-up data collection to evaluate treatment retention and recovery outcomes. Peer recovery support specialists participating in the study will: 1. Receive training and consultation. 2. Use implementation tools and supports designed to improve delivery of evidence-based parenting support. 3. Participate in implementation-related assessments and activities.

Participants needed: 288
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Baystate Medical CenterUpdated: Aug 20, 2026Locations: 1
Eligibility criteria

At least 18 years old or older [+3]

Status: Not yet recruiting

Recovery Opportunities Through Ongoing Treatment Sustainment

Adolescents in rural communities face limited access to effective substance use services, increasing their risk for opioid and other substance use disorders. This project will use an adaptive, iterative implementation approach to improve the integration of external substance use service providers into rural school settings. Findings will inform strategies to integrate and scale adolescent substance use services in schools. Support for this trial is provided by the HEAL Initiative (https://heal.nih.gov/).

Participants needed: 60
Trial details
Age: 13-18Biological sex: AllType: InterventionalSponsor: University of Maryland, College ParkUpdated: Aug 5, 2026
Eligibility criteria

Are enrolled in one of the participating schools [+2]

Demonstrating active, unstable or untreated psychiatric symptoms, including mani... [+1]

Status: Not yet recruiting

Supportive Treatment With Enhanced Post-Incarceration Services

This study aims to improve health outcomes for people who use drugs after release from incarceration, a period of high risk for overdose and other adverse outcomes. It will examine an individually tailored behavioral activation (IT-BA) intervention integrated into a reentry primary care program with peer support. The goal is to reduce substance use, improve mental health, and increase engagement in healthcare.

Participants needed: 120
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Catherine E. Paquette, PhDUpdated: Aug 4, 2026
Eligibility criteria

Be aged 18 years or older [+3]

Currently engaged in psychosocial treatment for drug use [+2]

Status: Recruiting

Cogito: A Turnkey Solution for Rapidly Developing, Evaluating, Deploying, and Scaling Digital Therapeutics

This is a research study to evaluate the usability of the Cogito digital therapeutics development platform. The Cogito platform is designed to allow researchers who are seeking to embed an evidence-based behavioral therapy into a digital delivery platform to do so via a drag and drop interface with no programming skills necessary. It will provide the components for building a digital therapeutic for any health condition and population. And in this initial study, the research team plans to examine the usability of Cogito in building a digital therapeutic for substance use disorders (SUDs).

Participants needed: 20
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Square2 Systems, Inc.Updated: Aug 11, 2025Locations: 1
Eligibility criteria

At least 18 years [+3]

Those who do not meet inclusion criteria.