Status: Recruiting

Phase II Decentralized Pragmatic Trial of Adjuvant Doxorubicin - Trabectedin Chemotherapy in uLMS

To find out if receiving standard chemotherapy (doxorubicin and trabectedin) can extend the cancer-free survival of patients with Stage 1b/2 uterine leiomyosarcoma who had surgery that fully removed the tumor.

Participants needed: 48

Trial details

Phase: Phase 2Age: 18+Biological sex: FemaleType: InterventionalSponsor: M.D. Anderson Cancer CenterUpdated: Aug 20, 2026Locations: 1

Eligibility criteria

Patients must have histologically confirmed uterine leiomyosarcoma [+19]

Patients who are receiving any other investigational agents. [+4]

Status: Recruiting

Letrozole in Uterine Leiomyosarcoma

This is a clinical trial to test letrozole in patients with uterine leiomyosarcoma. The main question is will treatment with letrozole extend progression-free survival in patients. Patients will receive 2/5 mg of letrozole daily.

Participants needed: 40

Trial details

Phase: Phase 2Age: 18+Biological sex: FemaleType: InterventionalSponsor: GOG FoundationUpdated: Jul 30, 2026Locations: 34

Eligibility criteria

Patient or a legally authorized representative must have signed an approved info... [+12]

Status: Recruiting

Ph 2 Elacestrant in ER Positive Uterine Sarcomas

This study is to evaluate the efficacy and safety of elacestrant, in participants with advanced estrogen receptor (ER)-positive uterine sarcomas. The name of the study drug involved in this research study is: -Elacestrant (a type of selective estrogen receptor degrader)

Participants needed: 30

Trial details

Phase: Phase 2Age: 18+Biological sex: FemaleType: InterventionalSponsor: Dana-Farber Cancer InstituteUpdated: May 22, 2026Locations: 1

Eligibility criteria

True abstinence when this is in line with the preferred and usual lifestyle of t... [+11]