Health TrialsbyHealthPanel

Clinical trials

2

Search and review clinical trials. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Zorifertinib With Osimertinib for NSCLC With Meningeal Progression

This is a clinical trial that aims to test Zorifertinib when used together with a known drug, Osimertinib. The goal is to learn if this combination is safe and works for people with advanced Non-Small Cell Lung Cancer (NSCLC) whose cancer has spread to the membranes surrounding the brain and spinal cord (a condition called leptomeningeal metastases) after being treated with Osimertinib.

Participants needed: 42
Trial details
Phase: Phase 1Age: 18+Biological sex: AllType: InterventionalSponsor: Alpha Biopharma (Jiangsu) Co., Ltd.Updated: Jun 22, 2026Locations: 5
Eligibility criteria

The patient or the guardian is required to understand and sign the informed cons... [+17]

Subjects who plan to receive brain radiotherapy or intrathecal injection during... [+6]

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Status: Recruiting

A Prospective Cohort Study of Zorifertinib as a First-line Treatment in Patients With Epidermal Growth Factor Receptor-mutant Advanced Non-small Cell Lung Cancer With Central Nervous System (CNS) Metastases

This study is a patient-centered, two-group, three-cohort, multi-center, prospective study to further evaluate the survival benefits and safety of zorifertinib as a first-line treatment in EGFRm+ advanced NSCLC patients with CNS metastases, and to compare the clinical value of zorifertinib with other epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs).

Participants needed: 800
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Alpha Biopharma (Jiangsu) Co., Ltd.Updated: Feb 9, 2026Locations: 34
Eligibility criteria

Male or female, aged ≥18 years. [+4]

Currently participating or planning to participate in any interventional clinica... [+44]

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