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Status: Not yet recruiting

Phase 3, Open-Label Extension Study of AMBTX-01 (Neridronate) for Complex Regional Pain Syndrome Type 1

A Phase 3 open-label extension study of AMBTX-01 (neridronate) for Complex Regional Pain Syndrome Type 1

Participants needed: 135
Trial details
Phase: Phase 3Age: 18+Biological sex: AllType: InterventionalSponsor: Ambros Therapeutics, Inc.Updated: Oct 5, 2026
Eligibility criteria

Participants must have completed the Week 12 visit of the neridronate AMBTX-01-3... [+8]

Individuals who did not participate in AMBTX-01-301 RCT, or those participants f... [+14]

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Status: Recruiting

CRPS-RISE Outcomes Registry

The goal of this observational study is to learn about how well neridronate keeps working in the months after treatment. For 12 or up to 24 months while the registry is open participants will answer online survey questions about their CRPS pain, medication use or procedures done and how CRPS affects what they are able to do.

Participants needed: 270
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Ambros Therapeutics, Inc.Updated: Sep 29, 2026Locations: 1Duration: 12 Months
Eligibility criteria

Participants from CRPS-RISE [+6]

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Status: Recruiting

Evaluation of IV AMBTX-01 (Neridronate) for Treatment of CRPS Type 1 (CRPS-RISE)

Phase 3 Trial of AMBTX-01 (neridronate) for Complex Regional Pain Syndrome Type 1

Participants needed: 270
Trial details
Phase: Phase 3Age: 18+Biological sex: AllType: InterventionalSponsor: Ambros Therapeutics, Inc.Updated: Sep 10, 2026Locations: 27
Eligibility criteria

Male or female participant ≥ 18 years of age at time of Screening. [+11]

A current or prior diagnosis of CRPS Type 2 or CRPS not otherwise specified (CRP... [+17]

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