Health Trials

Clinical trials

3

Search and review clinical trials. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

PM8002 (BNT327) in Combination With Chemotherapy in Patients With Metastatic Colorectal Cancer

PM8002 (BNT327) is a bispecific antibody targeting PD-L1 and VEGF. This is a phase II trial to evaluate the efficacy and safety of PM8002 in combination with chemotherapy in first line MSS or MSI-L/pMMR metastatic colorectal cancer.

Participants needed: 100
Trial details
Phase: Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: Biotheus Inc.Updated: Jul 23, 2026Locations: 11
Eligibility criteria

Signed informed consent form before any trial-related processes. [+7]

Received palliative local therapy, non-specific immunomodulatory therapy, or chi... [+7]

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Status: Not yet recruiting

A Study to Evaluate of PM8002 Combined With PM1009 in Patients With First-line HCC

This study to evaluate the preliminary efficacy, safety and pharmacokinetics of PM8002 combined with PM1009 in Patients with first-line Hepatocellular Carcinoma.

Participants needed: 140
Trial details
Phase: Phase 1, Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: Biotheus Inc.Updated: Dec 16, 2024
Eligibility criteria

Voluntary participation in clinical studies; [+8]

Pathologically confirmed fibrolamellar HCC, sarcomatoid HCC, cholangiocarcinoma... [+9]

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Status: Recruiting

PM8002 in the Treatment of Patients With Advanced Solid Tumors

This study is to characterize the safety, tolerability, pharmacokinetics (PK), immunogenicity, pharmacodynamics (PD) and anti-tumor activity of PM8002, a PD-L1/VEGF bispecific antibody, as a single agent in adult subjects with advanced solid tumors.

Participants needed: 380
Trial details
Phase: Phase 1, Phase 2Age: 18-75Biological sex: AllType: InterventionalSponsor: Biotheus Inc.Updated: Dec 5, 2024Locations: 48
Eligibility criteria

Voluntary participation in clinical study; fully understand the study and sign i... [+7]

History of severe allergic disease, severe allergy to drugs or known allergy to... [+10]

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